The effects of non-standard conditions on the application of the Gauss-Markov Theorem are discussed and methods proposed in the literature for dealing with these effects are reviewed. The multicollinearity problem, which is typified by imprecise least squares estimation of parameters in a multiple linear regression and which arises when the vectors of the input or predictor variables are nearly linearly dependent, is focussed upon and a class of alternative biased estimators examined. In particular several members of the class of biased linear estimators or linear transformations of the Gauss-Markov least squares estimator are reviewed. A particular generalized ridge estimator is introduced and its relation to other techniques already exist...