Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC(50) = 0.77 and 0.79 mu M, respectively) and excellent selectivity against melanoma and fibroblast cell lines. (C) 2009 Elsevier Ltd. All rights reserved.We are grateful to the Korea Institute of Science and Technology (KIST) for financial support