Add to ORKGUpon CD95/Fas ligation, the initiator caspase-8 is known to activate effector caspases leading to apoptosis. In the presence of zVAD-fmk, a broad-spectrum caspase inhibitor, Fas engagement can also trigger an alternative, non-apoptotic caspase-independent form of cell death, which is initiated by RIP1. Controversy exists as to the ability of caspase-10 to mediate cell death in response to FasL (CD95L or CD178). Herein, the role of caspase-10 in FasL-induced cell death has been re-evaluated
Activation of Fas receptor by Fas ligand causes caspase 8 activation and apoptosis in cells and is a...
Triggering of Fas (CD95) by its ligand (FasL) rapidly induces cell death via recruitment of the adap...
AbstractInitiation factor (eIF) 4G plays a key role in the regulation of translation, acting as a br...
Upon CD95/Fas ligation, the initiator caspase-8 is known to activate effector caspases leading to ap...
International audienceAltogether, these data provide genetic evidence for the involvement of initiat...
The activation of caspase-8, a crucial upstream mediator of death receptor signaling, was investigat...
AbstractBackground: Fas (APO-1/CD95) is a member of the tumor necrosis factor receptor (TNF-R) famil...
Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 an...
A role for cellular inhibitors of apoptosis (IAPs [cIAPs]) in preventing CD95 death has been suspect...
Certain caspase-8 null cell lines demonstrate resistance to Fas-induced apoptosis, indicating that t...
SummaryCD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis. ...
<p><b>A, B</b>, Casp10+ and Casp10- HeLa cells were incubated in the presence or absence of 40 µM zV...
AbstractThe activation of cysteine-aspartic proteases or caspases and the dynamic arrangement of cyt...
AbstractBackground: Activation of Fas (CD95) by its ligand (FasL) rapidly induces cell death through...
The mechanisms of how chemotherapeutic drugs lead to cell cycle checkpoint regulation and DNA damage...
Activation of Fas receptor by Fas ligand causes caspase 8 activation and apoptosis in cells and is a...
Triggering of Fas (CD95) by its ligand (FasL) rapidly induces cell death via recruitment of the adap...
AbstractInitiation factor (eIF) 4G plays a key role in the regulation of translation, acting as a br...
Upon CD95/Fas ligation, the initiator caspase-8 is known to activate effector caspases leading to ap...
International audienceAltogether, these data provide genetic evidence for the involvement of initiat...
The activation of caspase-8, a crucial upstream mediator of death receptor signaling, was investigat...
AbstractBackground: Fas (APO-1/CD95) is a member of the tumor necrosis factor receptor (TNF-R) famil...
Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 an...
A role for cellular inhibitors of apoptosis (IAPs [cIAPs]) in preventing CD95 death has been suspect...
Certain caspase-8 null cell lines demonstrate resistance to Fas-induced apoptosis, indicating that t...
SummaryCD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis. ...
<p><b>A, B</b>, Casp10+ and Casp10- HeLa cells were incubated in the presence or absence of 40 µM zV...
AbstractThe activation of cysteine-aspartic proteases or caspases and the dynamic arrangement of cyt...
AbstractBackground: Activation of Fas (CD95) by its ligand (FasL) rapidly induces cell death through...
The mechanisms of how chemotherapeutic drugs lead to cell cycle checkpoint regulation and DNA damage...
Activation of Fas receptor by Fas ligand causes caspase 8 activation and apoptosis in cells and is a...
Triggering of Fas (CD95) by its ligand (FasL) rapidly induces cell death via recruitment of the adap...
AbstractInitiation factor (eIF) 4G plays a key role in the regulation of translation, acting as a br...