Mid-regional proadrenomedullin: An early marker of response in critically ill patients with severe community-acquired pneumonia?

Pereira, JM
Azevedo, A
Basilio, C
Sousa-Dias, C
Mergulhao, P
Paiva, JA

Open link

Publication date

January 2016

DOI

10.1016/j.rppnen.2016.03.012

Publisher

Elsevier BV

Journal

Revista Portuguesa de Pneumologia (English Edition)

Abstract

BACKGROUND:Mid-regional proadrenomedullin (MR-proADM) is a novel biomarker with potential prognostic utility in patients with community-acquired pneumonia (CAP). PURPOSE:To evaluate the value of MR-proADM levels at ICU admission for further severity stratification and outcome prediction, and its kinetics as an early predictor of response in severe CAP (SCAP). MATERIALS AND METHODS:Prospective, single-center, cohort study of 19 SCAP patients admitted to the ICU within 12h after the first antibiotic dose. RESULTS:At ICU admission median MR-proADM was 3.58nmol/l (IQR: 2.83-10.00). No significant association was found between its serum levels at admission and severity assessed by SAPS II (Spearman's correlation=0.24, p=0.31) or SOFA score (SOFA...