Single-nucleotide polymorphisms in ETS1 are associated with systemic lupus erythematosus (SLE). Ets1(-/-) mice develop SLE-like symptoms, suggesting that dysregulation of this transcription factor is important to the onset or progression of SLE. We used conditional deletion approaches to examine the impact of Ets1 expression in different immune cell types. Ets1 deletion on CD4(+) T cells, but not B cells or dendritic cells, resulted in the SLE autoimmunity, and this was associated with the spontaneous expansion of T follicular helper type 2 (Tfh2) cells. Ets1(-/-) Tfh2 cells exhibited increased expression of GATA-3 and interleukin-4 (IL-4), which induced IgE isotype switching in B cells. Neutralization of IL-4 reduced Tfh2 cell frequencies ...
Ets1 is a member of the Ets transcription factor family. Alternative splicing of exon VII results in...
It has been established that CD4+ T cells play an essential role in the development of systemic lupu...
Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune disease, which m...
Single-nucleotide polymorphisms in ETS1 are associated with systemic lupus erythematosus (SLE). Ets1...
E26 transformation-specific-1 (Ets1) is a member of the Ets family of transcription factors and play...
E26 transformation-specific-1 (Ets1) is a member of the Ets family of transcription factors and play...
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) (Ets-1) is a member of the Ets family of...
Group 2 innate lymphoid cells ( ILC2s) are a subset of ILCs that play a protective role in the respo...
Genetic variants at chromosomal region 11q23.3, near the gene ETS1, have been associated with system...
Genetic variants at chromosomal region 11q23.3, near the gene ETS1, have been associated with system...
Atopic dermatitis (AD) is a complex inflammatory skin disease mediated by immune cells of both adapt...
International audienceRegulatory T cells (T reg cells) constitute a population of CD4(+) T cells tha...
International audienceTHE Ets-1 proto-oncogene is a member of a transcription factor family characte...
In response to antigens and cytokines, mouse B cells undergo class-switch re-combination (CSR) and d...
This study was designed to define gene expression and H3K4me3 histone modifications in T cells, B ce...
Ets1 is a member of the Ets transcription factor family. Alternative splicing of exon VII results in...
It has been established that CD4+ T cells play an essential role in the development of systemic lupu...
Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune disease, which m...
Single-nucleotide polymorphisms in ETS1 are associated with systemic lupus erythematosus (SLE). Ets1...
E26 transformation-specific-1 (Ets1) is a member of the Ets family of transcription factors and play...
E26 transformation-specific-1 (Ets1) is a member of the Ets family of transcription factors and play...
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) (Ets-1) is a member of the Ets family of...
Group 2 innate lymphoid cells ( ILC2s) are a subset of ILCs that play a protective role in the respo...
Genetic variants at chromosomal region 11q23.3, near the gene ETS1, have been associated with system...
Genetic variants at chromosomal region 11q23.3, near the gene ETS1, have been associated with system...
Atopic dermatitis (AD) is a complex inflammatory skin disease mediated by immune cells of both adapt...
International audienceRegulatory T cells (T reg cells) constitute a population of CD4(+) T cells tha...
International audienceTHE Ets-1 proto-oncogene is a member of a transcription factor family characte...
In response to antigens and cytokines, mouse B cells undergo class-switch re-combination (CSR) and d...
This study was designed to define gene expression and H3K4me3 histone modifications in T cells, B ce...
Ets1 is a member of the Ets transcription factor family. Alternative splicing of exon VII results in...
It has been established that CD4+ T cells play an essential role in the development of systemic lupu...
Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune disease, which m...