Defective gene expression of the membrane complement inhibitor CD46 in patients with progressive immunoglobulin A nephropathy
- Coppo, Rosanna
- Peruzzi, Licia
- Loiacono, Elisa
- Bergallo, Massimilano
- Krutova, Alexandra
- Russo, Maria Luisa
- Cocchi, Enrico
- Amore, Alessandro
- Lundberg, Sigrid
- Maixnerova, Dita
- Tesar, Vladimir
- Perkowska-Ptasinska, Agnieszka
- Durlik, Magdalena
- Goumenos, Dimitris
- Gerolymos, Miltiadis
- Galesic, Kresimir
- Toric, Luka
- Papagianni, Aikaterini
- Stangou, Maria
- Mizerska-Wasia Membek, Malgorzata
- Gesualdo, Loreto
- Montemurno, Eustacchio
- Benozzi, Luisa
- Cusinato, Stefano
- Hryszko, Tomasz
- Klinger, Marian
- Kaminska, Dorota
- Krajewska, Magdalena
DOIAbstract
Complement is thought to play a role in immunoglobulin A nephropathy (IgAN), though the activating mechanisms are unknown. This study focused on the gene expression of CD46 and CD55, two key molecules for regulating C3 convertase activity of lectin and alternative complement pathways at a cellular level
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