Background: Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower organisms. TRE exhibits an extraordinary ability to protect cells against different kinds of stresses through activation of autophagy. However, the effect of TRE on the heart during stress has never been tested. Objectives: This study evaluated the effects of TRE administration in a mouse model of chronic ischemic remodeling. Methods: Wild-type (WT) or beclin 1+/− mice were subjected to permanent ligation of the left anterior descending artery (LAD) and then treated with either placebo or trehalose (1 mg/g/day intraperitoneally for 48 h, then 2% in the drinking water). After 4 weeks, echocardiographic, hemodynamic, gravimetric, histological, and biochemi...
<div><p>Valvular diseases are common health problems that are strongly related to high morbidity and...
Valvular diseases are common health problems that are strongly related to high morbidity and mortali...
Objective: Autophagy is activated in ischemic heart diseases, but its dynamics and functional roles ...
Background: Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower organisms. T...
Background: Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower organisms. T...
BACKGROUND Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower organisms. TR...
Autophagy is an intracellular pathway that degrades unnecessary proteins and organelles and provides...
Atherosclerosis and nonalcoholic fatty liver disease (NAFLD) are frequent causes of death in the Wes...
Cerebrovascular disease, a frequent complication of hypertension, is a major public health issue for...
Autophagy attenuation has been found in neurodegenerative diseases, aging, diabetes mellitus, and at...
Bone marrow stromal stem cells (BMSCs) play a significant role in cell therapy. These cells quickly...
Coronary endothelial dysfunction is a major cause of ischemia-reperfusion (I/R) injury. Trehalose, a...
Bone marrow stromal stem cells (BMSCs) play a significant role in cell therapy. These cells quickly ...
Autophagy is a housekeeping process to remove damaged cytoplasmic constituents. However, a debate pe...
OBJECTIVE: Autophagy is activated in ischemic heart diseases, but its dynamics and functional roles ...
<div><p>Valvular diseases are common health problems that are strongly related to high morbidity and...
Valvular diseases are common health problems that are strongly related to high morbidity and mortali...
Objective: Autophagy is activated in ischemic heart diseases, but its dynamics and functional roles ...
Background: Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower organisms. T...
Background: Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower organisms. T...
BACKGROUND Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower organisms. TR...
Autophagy is an intracellular pathway that degrades unnecessary proteins and organelles and provides...
Atherosclerosis and nonalcoholic fatty liver disease (NAFLD) are frequent causes of death in the Wes...
Cerebrovascular disease, a frequent complication of hypertension, is a major public health issue for...
Autophagy attenuation has been found in neurodegenerative diseases, aging, diabetes mellitus, and at...
Bone marrow stromal stem cells (BMSCs) play a significant role in cell therapy. These cells quickly...
Coronary endothelial dysfunction is a major cause of ischemia-reperfusion (I/R) injury. Trehalose, a...
Bone marrow stromal stem cells (BMSCs) play a significant role in cell therapy. These cells quickly ...
Autophagy is a housekeeping process to remove damaged cytoplasmic constituents. However, a debate pe...
OBJECTIVE: Autophagy is activated in ischemic heart diseases, but its dynamics and functional roles ...
<div><p>Valvular diseases are common health problems that are strongly related to high morbidity and...
Valvular diseases are common health problems that are strongly related to high morbidity and mortali...
Objective: Autophagy is activated in ischemic heart diseases, but its dynamics and functional roles ...