Topics
chemotherapyTelevision station
antigenChemical compound
P-glycoproteinBiomolecule
PGPSoftware
acute myeloid leukemia (AML)Disease
Overexpression of P-glycoprotein (PGP), a multidrug-related (MDR) protein, is one of the most important factors responsible for reduced drug sensitivity in acute myeloid leukemia (AML). Recently, we demonstrated that the presence of CD56 antigen, an isoform of the neural adhesion molecule, in AML cells is a negative independent prognostic factor for the achievement of complete remission (CR) and correlates with shorter survival. Since in our previous report we observed a more frequent PGP expression in CD56+ patients, we hypothesized that the reduced response to chemotherapy in this group of patients was due to increased PGP-mediated drug efflux. To confirm this hypothesis in this study PGP and CD56 expression on AML cells was correlated wi...
The multidrug resistance proteins (MRPs) MRP1, MRP2, MRP3, MRP5 and P-glycoprotein (P-gp) act in con...
In acute myeloid leukemias (AMLs), multidrug resistance (MDR) is fre-quently, but not always, caused...
Purpose: P-glycoprotein (Pgp) is a major prognostic factor for chemotherapy failure in acute myeloid...
Overexpression of P-glycoprotein (PGP), a multidrug-related (MDR) protein, is one of the most import...
Acute myeloid leukemia (AML) is a heterogeneous group of disorders with distinct characteristics and...
Despite treatment with intensive chemotherapy, a considerable number of patients with acute myeloid ...
Preliminary reports suggest that leukemic cell expression of CD56, a neural cell adhesion molecule, ...
Background: The expression of CD56 is considered a bad prognostic factor for overall survival, lower...
The G-protein coupled receptor 56 (GPR56) was identified as part of the molecular signature of leuke...
Background: The most primitive leukemic precursor in acute myeloid leukemia (AML) is thought to be t...
Cytogenetic abnormalities are among the most important factors affecting the outcome of patients wit...
The multidrug resistance proteins (MRPs) MRP1, MRP2, MRP3, MRP5 and P-glycoprotein (P-gp) act in con...
In acute myeloid leukemias (AMLs), multidrug resistance (MDR) is fre-quently, but not always, caused...
Purpose: P-glycoprotein (Pgp) is a major prognostic factor for chemotherapy failure in acute myeloid...
Overexpression of P-glycoprotein (PGP), a multidrug-related (MDR) protein, is one of the most import...
Acute myeloid leukemia (AML) is a heterogeneous group of disorders with distinct characteristics and...
Despite treatment with intensive chemotherapy, a considerable number of patients with acute myeloid ...
Preliminary reports suggest that leukemic cell expression of CD56, a neural cell adhesion molecule, ...
Background: The expression of CD56 is considered a bad prognostic factor for overall survival, lower...
The G-protein coupled receptor 56 (GPR56) was identified as part of the molecular signature of leuke...
Background: The most primitive leukemic precursor in acute myeloid leukemia (AML) is thought to be t...
Cytogenetic abnormalities are among the most important factors affecting the outcome of patients wit...
The multidrug resistance proteins (MRPs) MRP1, MRP2, MRP3, MRP5 and P-glycoprotein (P-gp) act in con...
In acute myeloid leukemias (AMLs), multidrug resistance (MDR) is fre-quently, but not always, caused...
Purpose: P-glycoprotein (Pgp) is a major prognostic factor for chemotherapy failure in acute myeloid...
Add to ORKG