Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels.

Variants Associated with Secretory Phospholipase A2-IIA Levels

Exeter Holly J.
Folkersen Lasse
Palmen Jutta
Franco-Cereceda Anders
Cooper Jackie A.
Kalea Anastasia Z.
Hooft Ferdinand van’t
Eriksson Per
Humphries Steve E.
Talmud Philippa J.

July 2012

non-coding SNPs, rs11573156 C>G and rs3767221 T>G where the rare alleles have been previously assoc...

Secretory Phospholipase A(2)-IIA and Cardiovascular Disease

Holmes, Michael V.
Simon, Tabassome
Exeter, Holly J.
Folkersen, Lasse
Asselbergs, Folkert W.
Guardiola, Montse
Cooper, Jackie A.
Palmen, Jutta
Hubacek, Jaroslav A.
Carruthers, Kathryn F.
Horne, Benjamin D.
Brunisholz, Kimberly D.
Mega, Jessica L.
Van Iperen, Erik P. A.
Li, Mingyao
Leusink, Maarten
Trompet, Stella
Verschuren, Jeffrey J. W.
Hovingh, G. Kees
Dehghan, Abbas
Nelson, Christopher P.
Kotti, Salma
Danchin, Nicolas
Scholz, Markus
Haase, Christiane L.
Rothenbacher, Dietrich
Swerdlow, Daniel I.
Kuchenbaecker, Karoline B.
Staines-Urias, Eleonora
Goel, Anuj
van 't Hooft, Ferdinand
Gertow, Karl
de Faire, Ulf
Panayiotou, Andrie G.
Tremoli, Elena
Baldassarre, Damiano
Veglia, Fabrizio
Holdt, Lesca M.
Beutner, Frank
Gansevoort, Ron T.
Navis, Gerjan J.
Mateo Leach, Irene
Breitling, Lutz P.
Brenner, Hermann
Thiery, Joachim
Dallmeier, Dhayana
Franco-Cereceda, Anders
Boer, Jolanda M. A.
Stephens, Jeffrey W.
Hofker, Marten H.
Tedgui, Alain
Hofman, Albert
Uitterlinden, Andre G.
Adamkova, Vera
Pitha, Jan
Onland-Moret, N. Charlotte
Cramer, Maarten J.
Nathoe, Hendrik M.
Spiering, Wilko
Klungel, Olaf H.
Kumari, Meena
Whincup, Peter H.
Morrow, David A.
Braund, Peter S.
Hall, Alistair S.
Olsson, Anders G.
Doevendans, Pieter A.
Trip, Mieke D.
Tobin, Martin D.
Hamsten, Anders
Watkins, Hugh
Koenig, Wolfgang
Nicolaides, Andrew N.
Teupser, Daniel
Day, Ian N. M.
Carlquist, John F.
Gaunt, Tom R.
Ford, Ian
Sattar, Naveed
Tsimikas, Sotirios
Schwartz, Gregory G.
Lawlor, Debbie A.
Morris, Richard W.
Sandhu, Manjinder S.
Poledne, Rudolf
Maitland-van der Zee, Anke H.
Khaw, Kay-Tee
Keating, Brendan J.
van der Harst, Pim
Price, Jackie F.
Mehta, Shamir R.
Yusuf, Salim
Witteman, Jaqueline C. M.
Franco, Oscar H.
Jukema, J. Wouter
de Knijff, Peter
Tybjaerg-Hansen, Anne
Rader, Daniel J.
Farrall, Martin
Samani, Nilesh J.
Kivimaki, Mika
Fox, Keith A. A.
Humphries, Steve E.
Anderson, Jeffrey L.
Boekholdt, S. Matthijs
Palmer, Tom M.
Eriksson, Per
Pare, Guillaume
Hingorani, Aroon D.
Sabatine, Marc S.
Mallat, Ziad
Casas, Juan P.
Talmud, Philippa J.

November 2013

Objectives This study sought to investigate the role of secretory phospholipase A(2) (sPLA(2))-IIA i...

Translational Studies of Lipoprotein-Associated Phospholipase A2 in Inflammation and Atherosclerosis

Ferguson, Jane F.
Hinkle, Christine C.
Mehta, Nehal N.
Bagheri, Roshanak
DerOhannessian, Stephanie L.
Shah, Rhia
Mucksavage, Megan I.
Bradfield, Jonathan P.
Hakonarson, Hakon
Wang, Xuexia
Master, Stephen R.
Rader, Daniel J.
Li, Mingyao
Reilly, Muredach P.

February 2012

ObjectivesThis study sought to examine the role of lipoprotein-associated phospholipase A2 (Lp-PLA2/...

Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels.

Holly J Exeter
Lasse Folkersen
Jutta Palmen
Anders Franco-Cereceda
Jackie A Cooper
Anastasia Z Kalea
Ferdinand Van't Hooft
Per Eriksson
Steve E Humphries
Philippa J Talmud

Secretory phospholipase A2 group IIA (sPLA2-IIA) has been identified as a biomarker of atheroscleros...

Functional Analysis of Two PLA2G2A Variants Associated with Secretory Phospholipase A2-IIA Levels

Holly J. Exeter
Lasse Folkersen
Jutta Palmen
Anders Franco-cereceda
Jackie A. Cooper
Anastasia Z. Kalea
Per Eriksson
Steve E. Humphries

August 2016

Background: Secretory phospholipase A2 group IIA (sPLA2-IIA) has been identified as a biomarker of a...

Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels.

Holmes, Michael V
Exeter, Holly J
Folkersen, Lasse
Nelson, Christopher P
Guardiola, Montse
Cooper, Jackie A
Sofat, Reecha
Boekholdt, S Matthijs
Khaw, Kay-Tee
Li, Ka-Wah
Smith, Andrew J P
Van't Hooft, Ferdinand
Eriksson, Per
Franco-Cereceda, Anders
Asselbergs, Folkert W
Boer, Jolanda M A
Onland-Moret, N Charlotte
Hofker, Marten
Erdmann, Jeanette
Kivimaki, Mika
Kumari, Meena
Reiner, Alex P
Keating, Brendan J
Humphries, Steve E
Hingorani, Aroon D
Mallat, Ziad
Samani, Nilesh J
Talmud, Philippa J

January 2015

To access publisher's full text version of this article, please click on the hyperlink in Additional...

The genetic architecture of Secretory PLA2 (sPLA2)genes and their impact on sPLA2 activity/mass and association with CHD risk.

Exeter, HJ

December 2012

Secretory phospholipase A2 group (sPLA2) enzymes hydrolyze the sn-2 ester bond of phospholipids, pro...

Novel Genetic Approach to Investigate the Role of Plasma Secretory Phospholipase A2 (sPLA(2))-V Isoenzyme in Coronary Heart Disease Modified Mendelian Randomization Analysis Using PLA2G5 Expression Levels

Holmes, Michael V.
Exeter, Holly J.
Folkersen, Lasse
Nelson, Christopher P.
Guardiola, Montse
Cooper, Jackie A.
Sofat, Reecha
Boekholdt, S. Matthijs
Khaw, Kay-Tee
Li, Ka-Wah
Smith, Andrew J. P.
van't Hooft, Ferdinand
Eriksson, Per
Franco-Cereceda, Anders
Asselbergs, Folkert W.
Boer, Jolanda M. A.
Onland-Moret, N. Charlotte
Hofker, Marten
Erdmann, Jeanette
Kivimaki, Mika
Kumari, Meena
Reiner, Alex P.
Keating, Brendan J.
Humphries, Steve E.
Hingorani, Aroon D.
Mallat, Ziad
Samani, Nilesh J.
Talmud, Philippa J.

April 2014

Background- Secretory phospholipase A(2) (sPLA(2)) enzymes are considered to play a role in atherosc...

Novel Genetic Approach to Investigate the Role of Plasma Secretory Phospholipase A2 (sPLA <sub>2</sub> )-V Isoenzyme in Coronary Heart Disease

Holmes, Michael V
Exeter, Holly J
Folkersen, Lasse
Nelson, Christopher P
Guardiola, Montse
Cooper, Jackie A
Sofat, Reecha
Boekholdt, S Matthijs
Khaw, Kay-Tee
Li, Ka-Wah
Smith, Andrew JP
van’t Hooft, Ferdinand
Eriksson, Per
Franco-Cereceda, Anders
Asselbergs, Folkert W
Boer, Jolanda MA
Onland-Moret, N Charlotte
Hofker, Marten
Erdmann, Jeanette
Kivimaki, Mika
Kumari, Meena
Reiner, Alex P
Keating, Brendan J
Humphries, Steve E
Hingorani, Aroon D
Mallat, Ziad
Samani, Nilesh J
Talmud, Philippa J

April 2014

Background— Secretory phospholipase A 2 ...

PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk

Guardiola, Montse
Exeter, Holly
Perret, Claire
Folkersen, Lasse
Van'T Hooft, Ferdinand
Eriksson, Per
Franco-Cereceda, Anders
Paulsson-Berne, Gabrielle
Palmen, Jutta
Li, Kawah
Cooper, Jackie
Khaw, Kay-Tee
Mallat, Ziad
Ninio, Ewa
Karabina, Sonia-Athina
Humphries, Steve
Boekholdt, S Matthijs
Holmes, Michael
Talmud, Philippa

April 2015

International audienceBackground— Observational studies report that secretory phospholipase A2 (sPLA...

Genetic and functional studies of lipoprotein-associated phospholipase A2 and secretory phospholipase A2 variants: Their potential role in atherosclerosis

Wootton, PTE

January 2006

The aim of this thesis was to investigate the role of Lipoprotein-associated PLA2 (Lp-PLA2, PLA2G7) ...

Secretory Phospholipase A2 and Lipoprotein-Associated Phospholipase A2 as Biomarkers of Cardiovascular Disease and Therapeutic Targets

Tselepis, Alexandros D

March 2010

Atherosclerosis is not only a lipid-driven disease but it is an intricate process that also involves...

Secretory Phospholipase A2-IIA and Cardiovascular Disease A Mendelian Randomization Study

Holmes, Michael V.
Simon, Tabassome
Exeter, Holly J.
Folkersen, Lasse
Asselbergs, Folkert W.
Guardiola, Montse
Cooper, Jackie A.
Palmen, Jutta
Hubacek, Jaroslav A.
Carruthers, Kathryn F.
Horne, Benjamin D.
Brunisholz, Kimberly D.
Mega, Jessica L.
van Iperen, Erik P.A.
Li, Mingyao
Leusink, Maarten
Trompet, Stella
Verschuren, Jeffrey J.W.
Hovingh, G. Kees
Dehghan, Abbas
Nelson, Christopher P.
Kotti, Salma
Danchin, Nicolas
Scholz, Markus
Haase, Christiane L.
Rothenbacher, Dietrich
Swerdlow, Daniel I.
Kuchenbaecker, Karoline B.
Staines-Urias, Eleonora
Goel, Anuj
van 't Hooft, Ferdinand
Gertow, Karl
de Faire, Ulf
Panayiotou, Andrie G.
Tremoli, Elena
Baldassarre, Damiano
Veglia, Fabrizio
Holdt, Lesca M.
Beutner, Frank
Gansevoort, Ron T.
Navis, Gerjan J.
Mateo Leach, Irene
Breitling, Lutz P.
Brenner, Hermann
Thiery, Joachim
Dallmeier, Dhayana
Franco-Cereceda, Anders
Boer, Jolanda M.A.
Stephens, Jeffrey W.
Hofker, Marten H.
Tedgui, Alain
Hofman, Albert
Uitterlinden, André G.
Adamkova, Vera
Pitha, Jan
Onland-Moret, N. Charlotte
Cramer, Maarten J.
Nathoe, Hendrik M.
Spiering, Wilko
Klungel, Olaf H.
Kumari, Meena
Whincup, Peter H.
Morrow, David A.
Braund, Peter S.
Hall, Alistair S.
Olsson, Anders G.
Doevendans, Pieter A.
Trip, Mieke D.
Tobin, Martin D.
Hamsten, Anders
Watkins, Hugh
Koenig, Wolfgang
Nicolaides, Andrew N.
Teupser, Daniel
Day, Ian N.M.
Carlquist, John F.
Gaunt, Tom R.
Ford, Ian
Sattar, Naveed
Tsimikas, Sotirios
Schwartz, Gregory G.
Lawlor, Debbie A.
Morris, Richard W.
Sandhu, Manjinder S.
Poledne, Rudolf
Maitland-van der Zee, Anke H.
Khaw, Kay-Tee
Keating, Brendan J.
van der Harst, Pim
Price, Jackie F.
Mehta, Shamir R.
Yusuf, Salim
Witteman, Jaqueline C.M.
Franco, Oscar H.
Jukema, J. Wouter
de Knijff, Peter
Tybjaerg-Hansen, Anne
Rader, Daniel J.
Farrall, Martin
Samani, Nilesh J.
Kivimaki, Mika
Fox, Keith A.A.
Humphries, Steve E.
Anderson, Jeffrey L.
Boekholdt, S. Matthijs
Palmer, Tom M.
Eriksson, Per
Paré, Guillaume
Hingorani, Aroon D.
Sabatine, Marc S.
Mallat, Ziad
Casas, Juan P.
Talmud, Philippa J.

November 2013

ObjectivesThis study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in car...

Secretory phospholipase A2-IIA and cardiovascular disease: a mendelian randomization study

Holmes, Michael Vaclav
Simon, Tabassome
Exeter, Holly J.
Folkersen, Lasse
Asselbergs, Folkert W.
Guardiola, Montse
Cooper, Jackie A.
Palmen, Jutta A.
Hubacek, Jaroslav Alois
Carruthers, Kathryn F.
Horne, Benjamin D.
Adamkova, Vera
Baldassarre, Damiano
Veglia, Fabrizio
Holdt, Lesca Miriam
Beutner, Frank
Spiering, Wilko
Gansevoort, Ron T.
Navis, Gerjan J.
Breitling, Lutz Philipp H
Brenner, Hermann Hermann
Olsson, Anders G.
Thiery, Joachim J.
Dallmeier, Dhayana
Boer, Jolanda Ma A
Stephens, Jeffrey W.
Hofker, Marten
Tedgui, Alain S.
Watkins, Hugh C.
Hofman, Albert
Uitterlinden, Andre Gerardus
Piťha, Jan
Onland-Moret, N. Charlotte
Ford, Ian
Cramer, Maarten Jan M
Nathoe, H.
Klungel, Olaf H H
Kumari, Meena
Whincup, Peter H.
Morrow, David A.
Morris, Richard W.
Braund, Peter S.
Hall, Alistair S.
Doevendans, Pieter A F M
Trip, Mieke D.
Price, Jackie F.
Tobin, Martin D.
Hamsten, Anders
Koenig, Wolfgang
Nicolaides, Andrew N.
Teupser, Daniel
Day, Ian N.M.
Jukema, Johan Wouter Outer
Carlquist, John F.
Gaunt, Tom R.
Sattar, Naveed A.
Tsimikas, Sotirios
Fox, Keith A.A.
Schwartz, Gregory G.
Lawlor, Debbie A.
Sandhu, Manjinder S.
Poledne, Rudolf
Maitland-van Der Zee, Anke Hilse
Khaw, Kay Tee T
Eriksson, Per Olof
Keating, Brendan J.
Van Der Harst, Pim
Mehta, Shamir R.
Yusuf, Salim M.
Brunisholz, Kimberly D.
Witteman, Jacqueline C M
Franco, Oscar H.
De Knijff, Peter
Tybjærg-Hansen, Anne
Rader, Daniel J.
Farrall, Martin J.
Verschuren, Jeffrey J W
Samani, Nilesh
Kivimaki, Mika
Humphries, Steve Eric
Anderson, Jeffrey L.
Danchin, N.
Boekholdt, S. Matthijs
Palmer, Tom M.
Pare, Guillaume J.
Hingorani, Aroon D.
Sabatine, Marc S.
Mallat, Ziad
Goel, Anuj K.
Casas, Juan Pablo
Talmud, Philippa J.
Mega, Jessica
Van Iperen, Erik P A
Tremoli, Elena
Leusink, Maarten
Trompet, Stella
Hovingh, Gerald Kees
Dehghan, Abbas Jan
Nelson, Christopher P.
Kotti, Salma
Mateo Leach, Irene
Scholz, Markus R.
Haase, Christiane L.
Rothenbacher, Dietrich
Swerdlow, Daniel I.
Franco-Cereceda, Anders
Kuchenbaecker, Karoline B.
Staines-Urias, Eleonora
Van 'T Hooft, Ferdinand M.
Gertow, Karl
De Faire, Ulf H.
Panayiotou, Andrie G.

November 2013

Objectives This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in ca...

Secretory phospholipase A(2)-IIA and cardiovascular disease:a mendelian randomization study

Holmes, Michael V.
Simon, Tabassome
Exeter, Holly J.
Folkersen, Lasse
Asselbergs, Folkert W.
Guardiola, Montse
Cooper, Jackie A.
Palmen, Jutta
Hubacek, Jaroslav A.
Carruthers, Kathryn F.
Horne, Benjamin D.
Brunisholz, Kimberly D.
Mega, Jessica L.
van Iperen, Erik P. A.
Li, Mingyao
Leusink, Maarten
Trompet, Stella
Verschuren, Jeffrey J. W.
Hovingh, G. Kees
Dehghan, Abbas
Nelson, Christopher P.
Kotti, Salma
Danchin, Nicolas
Scholz, Markus
Haase, Christiane L.
Rothenbacher, Dietrich
Swerdlow, Daniel I.
Kuchenbaecker, Karoline B.
Staines-Urias, Eleonora
Goel, Anuj
van 't Hooft, Ferdinand
Gertow, Karl
de Faire, Ulf
Panayiotou, Andrie G.
Tremoli, Elena
Baldassarre, Damiano
Veglia, Fabrizio
Holdt, Lesca M.
Beutner, Frank
Gansevoort, Ron T.
Navis, Gerjan J.
Mateo Leach, Irene
Breitling, Lutz P.
Brenner, Hermann
Thiery, Joachim
Dallmeier, Dhayana
Franco-Cereceda, Anders
Boer, Jolanda M. A.
Stephens, Jeffrey W.
Hofker, Marten H.
Tedgui, Alain
Hofman, Albert
Uitterlinden, André G.
Adamkova, Vera
Pitha, Jan
Onland-Moret, N. Charlotte
Cramer, Maarten J.
Nathoe, Hendrik M.
Spiering, Wilko
Klungel, Olaf H.
Kumari, Meena
Whincup, Peter H.
Morrow, David A.
Braund, Peter S.
Hall, Alistair S.
Olsson, Anders G.
Doevendans, Pieter A.
Trip, Mieke D.
Tobin, Martin D.
Hamsten, Anders
Watkins, Hugh
Koenig, Wolfgang
Nicolaides, Andrew N.
Teupser, Daniel
Day, Ian N. M.
Carlquist, John F.
Gaunt, Tom R.
Ford, Ian
Sattar, Naveed
Tsimikas, Sotirios
Schwartz, Gregory G.
Lawlor, Debbie A.
Morris, Richard W.
Sandhu, Manjinder S.
Poledne, Rudolf
Maitland-van der Zee, Anke H.
Khaw, Kay-Tee
Keating, Brendan J.
van der Harst, Pim
Price, Jackie F.
Mehta, Shamir R.
Yusuf, Salim
Witteman, Jaqueline C. M.
Franco, Oscar H.
Jukema, J. Wouter
de Knijff, Peter
Tybjaerg-Hansen, Anne
Rader, Daniel J.
Farrall, Martin
Samani, Nilesh J.
Kivimaki, Mika
Fox, Keith A. A.
Humphries, Steve E.
Anderson, Jeffrey L.
Boekholdt, S. Matthijs
Palmer, Tom M.
Eriksson, Per
Paré, Guillaume
Hingorani, Aroon D.
Sabatine, Marc S.
Mallat, Ziad
Casas, Juan P.
Talmud, Philippa J.

November 2013

OBJECTIVES: This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in c...

Variants Associated with Secretory Phospholipase A2-IIA Levels

Exeter Holly J.
Folkersen Lasse
Palmen Jutta
Franco-Cereceda Anders
Cooper Jackie A.
Kalea Anastasia Z.
Hooft Ferdinand van’t
Eriksson Per
Humphries Steve E.
Talmud Philippa J.

July 2012

non-coding SNPs, rs11573156 C>G and rs3767221 T>G where the rare alleles have been previously assoc...

Secretory Phospholipase A(2)-IIA and Cardiovascular Disease

Holmes, Michael V.
Simon, Tabassome
Exeter, Holly J.
Folkersen, Lasse
Asselbergs, Folkert W.
Guardiola, Montse
Cooper, Jackie A.
Palmen, Jutta
Hubacek, Jaroslav A.
Carruthers, Kathryn F.
Horne, Benjamin D.
Brunisholz, Kimberly D.
Mega, Jessica L.
Van Iperen, Erik P. A.
Li, Mingyao
Leusink, Maarten
Trompet, Stella
Verschuren, Jeffrey J. W.
Hovingh, G. Kees
Dehghan, Abbas
Nelson, Christopher P.
Kotti, Salma
Danchin, Nicolas
Scholz, Markus
Haase, Christiane L.
Rothenbacher, Dietrich
Swerdlow, Daniel I.
Kuchenbaecker, Karoline B.
Staines-Urias, Eleonora
Goel, Anuj
van 't Hooft, Ferdinand
Gertow, Karl
de Faire, Ulf
Panayiotou, Andrie G.
Tremoli, Elena
Baldassarre, Damiano
Veglia, Fabrizio
Holdt, Lesca M.
Beutner, Frank
Gansevoort, Ron T.
Navis, Gerjan J.
Mateo Leach, Irene
Breitling, Lutz P.
Brenner, Hermann
Thiery, Joachim
Dallmeier, Dhayana
Franco-Cereceda, Anders
Boer, Jolanda M. A.
Stephens, Jeffrey W.
Hofker, Marten H.
Tedgui, Alain
Hofman, Albert
Uitterlinden, Andre G.
Adamkova, Vera
Pitha, Jan
Onland-Moret, N. Charlotte
Cramer, Maarten J.
Nathoe, Hendrik M.
Spiering, Wilko
Klungel, Olaf H.
Kumari, Meena
Whincup, Peter H.
Morrow, David A.
Braund, Peter S.
Hall, Alistair S.
Olsson, Anders G.
Doevendans, Pieter A.
Trip, Mieke D.
Tobin, Martin D.
Hamsten, Anders
Watkins, Hugh
Koenig, Wolfgang
Nicolaides, Andrew N.
Teupser, Daniel
Day, Ian N. M.
Carlquist, John F.
Gaunt, Tom R.
Ford, Ian
Sattar, Naveed
Tsimikas, Sotirios
Schwartz, Gregory G.
Lawlor, Debbie A.
Morris, Richard W.
Sandhu, Manjinder S.
Poledne, Rudolf
Maitland-van der Zee, Anke H.
Khaw, Kay-Tee
Keating, Brendan J.
van der Harst, Pim
Price, Jackie F.
Mehta, Shamir R.
Yusuf, Salim
Witteman, Jaqueline C. M.
Franco, Oscar H.
Jukema, J. Wouter
de Knijff, Peter
Tybjaerg-Hansen, Anne
Rader, Daniel J.
Farrall, Martin
Samani, Nilesh J.
Kivimaki, Mika
Fox, Keith A. A.
Humphries, Steve E.
Anderson, Jeffrey L.
Boekholdt, S. Matthijs
Palmer, Tom M.
Eriksson, Per
Pare, Guillaume
Hingorani, Aroon D.
Sabatine, Marc S.
Mallat, Ziad
Casas, Juan P.
Talmud, Philippa J.

November 2013

Objectives This study sought to investigate the role of secretory phospholipase A(2) (sPLA(2))-IIA i...

Translational Studies of Lipoprotein-Associated Phospholipase A2 in Inflammation and Atherosclerosis

Ferguson, Jane F.
Hinkle, Christine C.
Mehta, Nehal N.
Bagheri, Roshanak
DerOhannessian, Stephanie L.
Shah, Rhia
Mucksavage, Megan I.
Bradfield, Jonathan P.
Hakonarson, Hakon
Wang, Xuexia
Master, Stephen R.
Rader, Daniel J.
Li, Mingyao
Reilly, Muredach P.

February 2012

ObjectivesThis study sought to examine the role of lipoprotein-associated phospholipase A2 (Lp-PLA2/...

Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels.

Holly J Exeter
Lasse Folkersen
Jutta Palmen
Anders Franco-Cereceda
Jackie A Cooper
Anastasia Z Kalea
Ferdinand Van't Hooft
Per Eriksson
Steve E Humphries
Philippa J Talmud

Secretory phospholipase A2 group IIA (sPLA2-IIA) has been identified as a biomarker of atheroscleros...

Functional Analysis of Two PLA2G2A Variants Associated with Secretory Phospholipase A2-IIA Levels

Holly J. Exeter
Lasse Folkersen
Jutta Palmen
Anders Franco-cereceda
Jackie A. Cooper
Anastasia Z. Kalea
Per Eriksson
Steve E. Humphries

August 2016

Background: Secretory phospholipase A2 group IIA (sPLA2-IIA) has been identified as a biomarker of a...

Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels.

Holmes, Michael V
Exeter, Holly J
Folkersen, Lasse
Nelson, Christopher P
Guardiola, Montse
Cooper, Jackie A
Sofat, Reecha
Boekholdt, S Matthijs
Khaw, Kay-Tee
Li, Ka-Wah
Smith, Andrew J P
Van't Hooft, Ferdinand
Eriksson, Per
Franco-Cereceda, Anders
Asselbergs, Folkert W
Boer, Jolanda M A
Onland-Moret, N Charlotte
Hofker, Marten
Erdmann, Jeanette
Kivimaki, Mika
Kumari, Meena
Reiner, Alex P
Keating, Brendan J
Humphries, Steve E
Hingorani, Aroon D
Mallat, Ziad
Samani, Nilesh J
Talmud, Philippa J

January 2015

To access publisher's full text version of this article, please click on the hyperlink in Additional...

The genetic architecture of Secretory PLA2 (sPLA2)genes and their impact on sPLA2 activity/mass and association with CHD risk.

Exeter, HJ

December 2012

Secretory phospholipase A2 group (sPLA2) enzymes hydrolyze the sn-2 ester bond of phospholipids, pro...

Novel Genetic Approach to Investigate the Role of Plasma Secretory Phospholipase A2 (sPLA(2))-V Isoenzyme in Coronary Heart Disease Modified Mendelian Randomization Analysis Using PLA2G5 Expression Levels

Holmes, Michael V.
Exeter, Holly J.
Folkersen, Lasse
Nelson, Christopher P.
Guardiola, Montse
Cooper, Jackie A.
Sofat, Reecha
Boekholdt, S. Matthijs
Khaw, Kay-Tee
Li, Ka-Wah
Smith, Andrew J. P.
van't Hooft, Ferdinand
Eriksson, Per
Franco-Cereceda, Anders
Asselbergs, Folkert W.
Boer, Jolanda M. A.
Onland-Moret, N. Charlotte
Hofker, Marten
Erdmann, Jeanette
Kivimaki, Mika
Kumari, Meena
Reiner, Alex P.
Keating, Brendan J.
Humphries, Steve E.
Hingorani, Aroon D.
Mallat, Ziad
Samani, Nilesh J.
Talmud, Philippa J.

April 2014

Background- Secretory phospholipase A(2) (sPLA(2)) enzymes are considered to play a role in atherosc...

Novel Genetic Approach to Investigate the Role of Plasma Secretory Phospholipase A2 (sPLA <sub>2</sub> )-V Isoenzyme in Coronary Heart Disease

Holmes, Michael V
Exeter, Holly J
Folkersen, Lasse
Nelson, Christopher P
Guardiola, Montse
Cooper, Jackie A
Sofat, Reecha
Boekholdt, S Matthijs
Khaw, Kay-Tee
Li, Ka-Wah
Smith, Andrew JP
van’t Hooft, Ferdinand
Eriksson, Per
Franco-Cereceda, Anders
Asselbergs, Folkert W
Boer, Jolanda MA
Onland-Moret, N Charlotte
Hofker, Marten
Erdmann, Jeanette
Kivimaki, Mika
Kumari, Meena
Reiner, Alex P
Keating, Brendan J
Humphries, Steve E
Hingorani, Aroon D
Mallat, Ziad
Samani, Nilesh J
Talmud, Philippa J

April 2014

Background— Secretory phospholipase A 2 ...

PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk

Guardiola, Montse
Exeter, Holly
Perret, Claire
Folkersen, Lasse
Van'T Hooft, Ferdinand
Eriksson, Per
Franco-Cereceda, Anders
Paulsson-Berne, Gabrielle
Palmen, Jutta
Li, Kawah
Cooper, Jackie
Khaw, Kay-Tee
Mallat, Ziad
Ninio, Ewa
Karabina, Sonia-Athina
Humphries, Steve
Boekholdt, S Matthijs
Holmes, Michael
Talmud, Philippa

April 2015

International audienceBackground— Observational studies report that secretory phospholipase A2 (sPLA...

Genetic and functional studies of lipoprotein-associated phospholipase A2 and secretory phospholipase A2 variants: Their potential role in atherosclerosis

Wootton, PTE

January 2006

The aim of this thesis was to investigate the role of Lipoprotein-associated PLA2 (Lp-PLA2, PLA2G7) ...

Secretory Phospholipase A2 and Lipoprotein-Associated Phospholipase A2 as Biomarkers of Cardiovascular Disease and Therapeutic Targets

Tselepis, Alexandros D

March 2010

Atherosclerosis is not only a lipid-driven disease but it is an intricate process that also involves...

Secretory Phospholipase A2-IIA and Cardiovascular Disease A Mendelian Randomization Study

Holmes, Michael V.
Simon, Tabassome
Exeter, Holly J.
Folkersen, Lasse
Asselbergs, Folkert W.
Guardiola, Montse
Cooper, Jackie A.
Palmen, Jutta
Hubacek, Jaroslav A.
Carruthers, Kathryn F.
Horne, Benjamin D.
Brunisholz, Kimberly D.
Mega, Jessica L.
van Iperen, Erik P.A.
Li, Mingyao
Leusink, Maarten
Trompet, Stella
Verschuren, Jeffrey J.W.
Hovingh, G. Kees
Dehghan, Abbas
Nelson, Christopher P.
Kotti, Salma
Danchin, Nicolas
Scholz, Markus
Haase, Christiane L.
Rothenbacher, Dietrich
Swerdlow, Daniel I.
Kuchenbaecker, Karoline B.
Staines-Urias, Eleonora
Goel, Anuj
van 't Hooft, Ferdinand
Gertow, Karl
de Faire, Ulf
Panayiotou, Andrie G.
Tremoli, Elena
Baldassarre, Damiano
Veglia, Fabrizio
Holdt, Lesca M.
Beutner, Frank
Gansevoort, Ron T.
Navis, Gerjan J.
Mateo Leach, Irene
Breitling, Lutz P.
Brenner, Hermann
Thiery, Joachim
Dallmeier, Dhayana
Franco-Cereceda, Anders
Boer, Jolanda M.A.
Stephens, Jeffrey W.
Hofker, Marten H.
Tedgui, Alain
Hofman, Albert
Uitterlinden, André G.
Adamkova, Vera
Pitha, Jan
Onland-Moret, N. Charlotte
Cramer, Maarten J.
Nathoe, Hendrik M.
Spiering, Wilko
Klungel, Olaf H.
Kumari, Meena
Whincup, Peter H.
Morrow, David A.
Braund, Peter S.
Hall, Alistair S.
Olsson, Anders G.
Doevendans, Pieter A.
Trip, Mieke D.
Tobin, Martin D.
Hamsten, Anders
Watkins, Hugh
Koenig, Wolfgang
Nicolaides, Andrew N.
Teupser, Daniel
Day, Ian N.M.
Carlquist, John F.
Gaunt, Tom R.
Ford, Ian
Sattar, Naveed
Tsimikas, Sotirios
Schwartz, Gregory G.
Lawlor, Debbie A.
Morris, Richard W.
Sandhu, Manjinder S.
Poledne, Rudolf
Maitland-van der Zee, Anke H.
Khaw, Kay-Tee
Keating, Brendan J.
van der Harst, Pim
Price, Jackie F.
Mehta, Shamir R.
Yusuf, Salim
Witteman, Jaqueline C.M.
Franco, Oscar H.
Jukema, J. Wouter
de Knijff, Peter
Tybjaerg-Hansen, Anne
Rader, Daniel J.
Farrall, Martin
Samani, Nilesh J.
Kivimaki, Mika
Fox, Keith A.A.
Humphries, Steve E.
Anderson, Jeffrey L.
Boekholdt, S. Matthijs
Palmer, Tom M.
Eriksson, Per
Paré, Guillaume
Hingorani, Aroon D.
Sabatine, Marc S.
Mallat, Ziad
Casas, Juan P.
Talmud, Philippa J.

November 2013

ObjectivesThis study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in car...

Secretory phospholipase A2-IIA and cardiovascular disease: a mendelian randomization study

Holmes, Michael Vaclav
Simon, Tabassome
Exeter, Holly J.
Folkersen, Lasse
Asselbergs, Folkert W.
Guardiola, Montse
Cooper, Jackie A.
Palmen, Jutta A.
Hubacek, Jaroslav Alois
Carruthers, Kathryn F.
Horne, Benjamin D.
Adamkova, Vera
Baldassarre, Damiano
Veglia, Fabrizio
Holdt, Lesca Miriam
Beutner, Frank
Spiering, Wilko
Gansevoort, Ron T.
Navis, Gerjan J.
Breitling, Lutz Philipp H
Brenner, Hermann Hermann
Olsson, Anders G.
Thiery, Joachim J.
Dallmeier, Dhayana
Boer, Jolanda Ma A
Stephens, Jeffrey W.
Hofker, Marten
Tedgui, Alain S.
Watkins, Hugh C.
Hofman, Albert
Uitterlinden, Andre Gerardus
Piťha, Jan
Onland-Moret, N. Charlotte
Ford, Ian
Cramer, Maarten Jan M
Nathoe, H.
Klungel, Olaf H H
Kumari, Meena
Whincup, Peter H.
Morrow, David A.
Morris, Richard W.
Braund, Peter S.
Hall, Alistair S.
Doevendans, Pieter A F M
Trip, Mieke D.
Price, Jackie F.
Tobin, Martin D.
Hamsten, Anders
Koenig, Wolfgang
Nicolaides, Andrew N.
Teupser, Daniel
Day, Ian N.M.
Jukema, Johan Wouter Outer
Carlquist, John F.
Gaunt, Tom R.
Sattar, Naveed A.
Tsimikas, Sotirios
Fox, Keith A.A.
Schwartz, Gregory G.
Lawlor, Debbie A.
Sandhu, Manjinder S.
Poledne, Rudolf
Maitland-van Der Zee, Anke Hilse
Khaw, Kay Tee T
Eriksson, Per Olof
Keating, Brendan J.
Van Der Harst, Pim
Mehta, Shamir R.
Yusuf, Salim M.
Brunisholz, Kimberly D.
Witteman, Jacqueline C M
Franco, Oscar H.
De Knijff, Peter
Tybjærg-Hansen, Anne
Rader, Daniel J.
Farrall, Martin J.
Verschuren, Jeffrey J W
Samani, Nilesh
Kivimaki, Mika
Humphries, Steve Eric
Anderson, Jeffrey L.
Danchin, N.
Boekholdt, S. Matthijs
Palmer, Tom M.
Pare, Guillaume J.
Hingorani, Aroon D.
Sabatine, Marc S.
Mallat, Ziad
Goel, Anuj K.
Casas, Juan Pablo
Talmud, Philippa J.
Mega, Jessica
Van Iperen, Erik P A
Tremoli, Elena
Leusink, Maarten
Trompet, Stella
Hovingh, Gerald Kees
Dehghan, Abbas Jan
Nelson, Christopher P.
Kotti, Salma
Mateo Leach, Irene
Scholz, Markus R.
Haase, Christiane L.
Rothenbacher, Dietrich
Swerdlow, Daniel I.
Franco-Cereceda, Anders
Kuchenbaecker, Karoline B.
Staines-Urias, Eleonora
Van 'T Hooft, Ferdinand M.
Gertow, Karl
De Faire, Ulf H.
Panayiotou, Andrie G.

November 2013

Objectives This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in ca...

Secretory phospholipase A(2)-IIA and cardiovascular disease:a mendelian randomization study

Holmes, Michael V.
Simon, Tabassome
Exeter, Holly J.
Folkersen, Lasse
Asselbergs, Folkert W.
Guardiola, Montse
Cooper, Jackie A.
Palmen, Jutta
Hubacek, Jaroslav A.
Carruthers, Kathryn F.
Horne, Benjamin D.
Brunisholz, Kimberly D.
Mega, Jessica L.
van Iperen, Erik P. A.
Li, Mingyao
Leusink, Maarten
Trompet, Stella
Verschuren, Jeffrey J. W.
Hovingh, G. Kees
Dehghan, Abbas
Nelson, Christopher P.
Kotti, Salma
Danchin, Nicolas
Scholz, Markus
Haase, Christiane L.
Rothenbacher, Dietrich
Swerdlow, Daniel I.
Kuchenbaecker, Karoline B.
Staines-Urias, Eleonora
Goel, Anuj
van 't Hooft, Ferdinand
Gertow, Karl
de Faire, Ulf
Panayiotou, Andrie G.
Tremoli, Elena
Baldassarre, Damiano
Veglia, Fabrizio
Holdt, Lesca M.
Beutner, Frank
Gansevoort, Ron T.
Navis, Gerjan J.
Mateo Leach, Irene
Breitling, Lutz P.
Brenner, Hermann
Thiery, Joachim
Dallmeier, Dhayana
Franco-Cereceda, Anders
Boer, Jolanda M. A.
Stephens, Jeffrey W.
Hofker, Marten H.
Tedgui, Alain
Hofman, Albert
Uitterlinden, André G.
Adamkova, Vera
Pitha, Jan
Onland-Moret, N. Charlotte
Cramer, Maarten J.
Nathoe, Hendrik M.
Spiering, Wilko
Klungel, Olaf H.
Kumari, Meena
Whincup, Peter H.
Morrow, David A.
Braund, Peter S.
Hall, Alistair S.
Olsson, Anders G.
Doevendans, Pieter A.
Trip, Mieke D.
Tobin, Martin D.
Hamsten, Anders
Watkins, Hugh
Koenig, Wolfgang
Nicolaides, Andrew N.
Teupser, Daniel
Day, Ian N. M.
Carlquist, John F.
Gaunt, Tom R.
Ford, Ian
Sattar, Naveed
Tsimikas, Sotirios
Schwartz, Gregory G.
Lawlor, Debbie A.
Morris, Richard W.
Sandhu, Manjinder S.
Poledne, Rudolf
Maitland-van der Zee, Anke H.
Khaw, Kay-Tee
Keating, Brendan J.
van der Harst, Pim
Price, Jackie F.
Mehta, Shamir R.
Yusuf, Salim
Witteman, Jaqueline C. M.
Franco, Oscar H.
Jukema, J. Wouter
de Knijff, Peter
Tybjaerg-Hansen, Anne
Rader, Daniel J.
Farrall, Martin
Samani, Nilesh J.
Kivimaki, Mika
Fox, Keith A. A.
Humphries, Steve E.
Anderson, Jeffrey L.
Boekholdt, S. Matthijs
Palmer, Tom M.
Eriksson, Per
Paré, Guillaume
Hingorani, Aroon D.
Sabatine, Marc S.
Mallat, Ziad
Casas, Juan P.
Talmud, Philippa J.

November 2013

OBJECTIVES: This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in c...

Variants Associated with Secretory Phospholipase A2-IIA Levels

Exeter Holly J.
Folkersen Lasse
Palmen Jutta
Franco-Cereceda Anders
Cooper Jackie A.
Kalea Anastasia Z.
Hooft Ferdinand van’t
Eriksson Per
Humphries Steve E.
Talmud Philippa J.

July 2012

non-coding SNPs, rs11573156 C>G and rs3767221 T>G where the rare alleles have been previously assoc...

Secretory Phospholipase A(2)-IIA and Cardiovascular Disease

Holmes, Michael V.
Simon, Tabassome
Exeter, Holly J.
Folkersen, Lasse
Asselbergs, Folkert W.
Guardiola, Montse
Cooper, Jackie A.
Palmen, Jutta
Hubacek, Jaroslav A.
Carruthers, Kathryn F.
Horne, Benjamin D.
Brunisholz, Kimberly D.
Mega, Jessica L.
Van Iperen, Erik P. A.
Li, Mingyao
Leusink, Maarten
Trompet, Stella
Verschuren, Jeffrey J. W.
Hovingh, G. Kees
Dehghan, Abbas
Nelson, Christopher P.
Kotti, Salma
Danchin, Nicolas
Scholz, Markus
Haase, Christiane L.
Rothenbacher, Dietrich
Swerdlow, Daniel I.
Kuchenbaecker, Karoline B.
Staines-Urias, Eleonora
Goel, Anuj
van 't Hooft, Ferdinand
Gertow, Karl
de Faire, Ulf
Panayiotou, Andrie G.
Tremoli, Elena
Baldassarre, Damiano
Veglia, Fabrizio
Holdt, Lesca M.
Beutner, Frank
Gansevoort, Ron T.
Navis, Gerjan J.
Mateo Leach, Irene
Breitling, Lutz P.
Brenner, Hermann
Thiery, Joachim
Dallmeier, Dhayana
Franco-Cereceda, Anders
Boer, Jolanda M. A.
Stephens, Jeffrey W.
Hofker, Marten H.
Tedgui, Alain
Hofman, Albert
Uitterlinden, Andre G.
Adamkova, Vera
Pitha, Jan
Onland-Moret, N. Charlotte
Cramer, Maarten J.
Nathoe, Hendrik M.
Spiering, Wilko
Klungel, Olaf H.
Kumari, Meena
Whincup, Peter H.
Morrow, David A.
Braund, Peter S.
Hall, Alistair S.
Olsson, Anders G.
Doevendans, Pieter A.
Trip, Mieke D.
Tobin, Martin D.
Hamsten, Anders
Watkins, Hugh
Koenig, Wolfgang
Nicolaides, Andrew N.
Teupser, Daniel
Day, Ian N. M.
Carlquist, John F.
Gaunt, Tom R.
Ford, Ian
Sattar, Naveed
Tsimikas, Sotirios
Schwartz, Gregory G.
Lawlor, Debbie A.
Morris, Richard W.
Sandhu, Manjinder S.
Poledne, Rudolf
Maitland-van der Zee, Anke H.
Khaw, Kay-Tee
Keating, Brendan J.
van der Harst, Pim
Price, Jackie F.
Mehta, Shamir R.
Yusuf, Salim
Witteman, Jaqueline C. M.
Franco, Oscar H.
Jukema, J. Wouter
de Knijff, Peter
Tybjaerg-Hansen, Anne
Rader, Daniel J.
Farrall, Martin
Samani, Nilesh J.
Kivimaki, Mika
Fox, Keith A. A.
Humphries, Steve E.
Anderson, Jeffrey L.
Boekholdt, S. Matthijs
Palmer, Tom M.
Eriksson, Per
Pare, Guillaume
Hingorani, Aroon D.
Sabatine, Marc S.
Mallat, Ziad
Casas, Juan P.
Talmud, Philippa J.

November 2013

Objectives This study sought to investigate the role of secretory phospholipase A(2) (sPLA(2))-IIA i...

Translational Studies of Lipoprotein-Associated Phospholipase A2 in Inflammation and Atherosclerosis

Ferguson, Jane F.
Hinkle, Christine C.
Mehta, Nehal N.
Bagheri, Roshanak
DerOhannessian, Stephanie L.
Shah, Rhia
Mucksavage, Megan I.
Bradfield, Jonathan P.
Hakonarson, Hakon
Wang, Xuexia
Master, Stephen R.
Rader, Daniel J.
Li, Mingyao
Reilly, Muredach P.

February 2012

ObjectivesThis study sought to examine the role of lipoprotein-associated phospholipase A2 (Lp-PLA2/...

Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels.

Abstract

Extracted data

Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels.

Abstract

Extracted data

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