Cancer stem cell-associated pathways regulating chemoresistance in ovarian cancer

Chan, Emily Phee Ern

Publication date

January 2017

Abstract

© 2017 Dr. Emily Phee Ern ChanEpithelial ovarian cancer (EOC) is the most lethal of the gynaecologic malignancies, with an overall 5-year survival rate of only <30%. This poor prognosis is due to the advanced-stage disease at initial diagnosis in approximately 70% of women. Despite good initial response to chemotherapy treatment, almost 80% of these patients will relapse and ultimately die within 5 years due to the development of chemoresistant recurrent disease. Emerging evidence suggests that a subpopulation of cancer stem cells (CSCs) that possess stem cell-like self-renewal and pluripotency properties are responsible for drug resistance and disease recurrence. The results from this thesis demonstrated that the expression of JAK2, STAT3,...

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Cancer stem cell-associated pathways regulating chemoresistance in ovarian cancer

Abstract

Extracted data

Cancer stem cell-associated pathways regulating chemoresistance in ovarian cancer

Abstract

Extracted data

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