© 2017 Dr Stuart PortburyA consequence of traumatic brain injury (TBI) is the sudden and dramatic change in concentration of the biological transition metals zinc, iron and copper. These changes are thought to contribute to the neuronal pathologies that occur following TBI. The transition metal zinc is particularly implicated in the ‘metallo-pathological’ progression post-TBI, due to the liberation of toxic zinc ions immediately after injury, and zinc deficiency as a further clinical outcome. Importantly, zinc, iron and copper are involved in the cellular cascades leading to the defining pathologies of Alzheimer’s disease (AD), one of several neurodegenerative conditions that TBI is postulated to be antecedent to. In this thesis, I...
The overall effect of brain zinc (Zn(2+)) in the progression and development of Alzheimer's disease ...
© 2014 Dr. Laura BicaAlzheimer’s disease (AD) is caused by a myriad of complex pathological factors ...
In this special issue about biofactors causing cognitive impairment, we present evidence for and dis...
Traumatic brain Injury (TBI) is a significant cause of death and long-term disability for which ther...
Traumatic brain Injury (TBI) is a significant cause of death and long-term disability for which ther...
This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose...
This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose...
Traumatic brain injury (TBI) is one of the leading causes of disability and death among young people...
© 2017 The Royal Society of Chemistry. The biological transition metals iron (Fe), copper (Cu) and z...
Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism ...
Metal ions, particularly copper, zinc and iron, are implicated in several amyloidogenic neurodegener...
Metal ions, particularly copper, zinc and iron, are implicated in several amyloidogenic neurodegener...
© 2016 The Royal Society of Chemistry. Traumatic brain injury (TBI) is complicated by a sudden and d...
Abstract: Zinc (Zn) is an essential trace element that is abundantly present in the brain. Despite i...
In recent years, soluble amyloid beta oligomers (AßO) have emerged as key elements in the cascade le...
The overall effect of brain zinc (Zn(2+)) in the progression and development of Alzheimer's disease ...
© 2014 Dr. Laura BicaAlzheimer’s disease (AD) is caused by a myriad of complex pathological factors ...
In this special issue about biofactors causing cognitive impairment, we present evidence for and dis...
Traumatic brain Injury (TBI) is a significant cause of death and long-term disability for which ther...
Traumatic brain Injury (TBI) is a significant cause of death and long-term disability for which ther...
This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose...
This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose...
Traumatic brain injury (TBI) is one of the leading causes of disability and death among young people...
© 2017 The Royal Society of Chemistry. The biological transition metals iron (Fe), copper (Cu) and z...
Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism ...
Metal ions, particularly copper, zinc and iron, are implicated in several amyloidogenic neurodegener...
Metal ions, particularly copper, zinc and iron, are implicated in several amyloidogenic neurodegener...
© 2016 The Royal Society of Chemistry. Traumatic brain injury (TBI) is complicated by a sudden and d...
Abstract: Zinc (Zn) is an essential trace element that is abundantly present in the brain. Despite i...
In recent years, soluble amyloid beta oligomers (AßO) have emerged as key elements in the cascade le...
The overall effect of brain zinc (Zn(2+)) in the progression and development of Alzheimer's disease ...
© 2014 Dr. Laura BicaAlzheimer’s disease (AD) is caused by a myriad of complex pathological factors ...
In this special issue about biofactors causing cognitive impairment, we present evidence for and dis...