Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
- Vithana, EN
- Khor, C-C
- Qiao, C
- Nongpiur, ME
- George, R
- Chen, L-J
- Tan, D
- Abu-Amero, KK
- Huang, CK
- Low, S
- Tajudin, L-SA
- Perera, SA
- Cheng, C-Y
- Xu, L
- Jia, H
- Ho, C-L
- Sim, KS
- Wu, R-Y
- Tham, CCY
- Chew, PTK
- Su, DH
- Oen, FT
- Sarangapani, S
- Soumittra, N
- Osman, EA
- Wong, H-T
- Tang, G
- Fan, S
- Meng, H
- Huong, DTL
- Wang, H
- Feng, B
- Baskaran, M
- Shantha, B
- Ramprasad, VL
- Kumaramanickavel, G
- Iyengar, SK
- How, AC
- Lee, KY
- Sivakumaran, TA
- Yong, VHK
- Ting, SML
- Li, Y
- Wang, Y-X
- Tay, W-T
- Sim, X
- Lavanya, R
- Cornes, BK
- Zheng, Y-F
- Wong, TT
- Loon, S-C
- Yong, VKY
- Waseem, N
- Yaakub, A
- Chia, K-S
- Allingham, RR
- Hauser, MA
- Lam, DSC
- Hibberd, ML
- Bhattacharya, SS
- Zhang, M
- Teo, YY
- Tan, DT
- Jonas, JB
- Tai, E-S
- Saw, S-M
- Do, NH
- Al-Obeidan, SA
- Liu, J
- Tran, NBC
- Simmons, CP
- Bei, J-X
- Zeng, Y-X
- Foster, PJ
- Vijaya, L
- Wong, T-Y
- Pang, C-P
- Wang, N
- Aung, T
DOIAbstract
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR)=1.22; P=5.33×10(-12)), rs3753841 in COL11A1 (per-allele OR=1.20; P=9.22×10(-10)) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR=1.50; P=3.29×10(-9)). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of ...
Add to ORKG