OBJECTIVE: Colorectal cancer (CRC) has a substantial heritable component. Common genetic variation has been shown to contribute to CRC risk. A study was conducted in a large multi-population study to assess the feasibility of CRC risk prediction using common genetic variant data combined with other risk factors. A risk prediction model was built and applied to the Scottish population using available data. DESIGN: Nine populations of European descent were studied to develop and validate CRC risk prediction models. Binary logistic regression was used to assess the combined effect of age, gender, family history (FH) and genotypes at 10 susceptibility loci that individually only modestly influence CRC risk. Risk models were generated from case-...
Background & AimsEarly-onset colorectal cancer (CRC, in persons younger than 50 years old) is increa...
In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we...
Genome-wide association studies have been successful in elucidating the genetic basis of colorectal ...
Accurate colorectal cancer (CRC) risk prediction models are critical for identifying individuals at ...
Background and aims: Summarised in polygenic risk scores (PRS), the effect of common, low penetrant ...
OBJECTIVE: Colorectal cancer (CRC) has a substantial heritable component. Common genetic variation h...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P -8) associate...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8) a...
BackgroundPrevious genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) ...
Purpose This study investigated the utility of modeling modifiable lifestyle risk factors in additio...
Purpose: To date, genomewide association studies have identified 10 genetic loci associated with col...
Colorectal cancer (CRC) screening of the average risk population is only indicated according to age....
Colorectal cancer (CRC) screening of the average risk population is only indicated a...
Colorectal cancer (CRC) is the third most common global cancer. Approximately one fifth of phenotypi...
Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence...
Background & AimsEarly-onset colorectal cancer (CRC, in persons younger than 50 years old) is increa...
In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we...
Genome-wide association studies have been successful in elucidating the genetic basis of colorectal ...
Accurate colorectal cancer (CRC) risk prediction models are critical for identifying individuals at ...
Background and aims: Summarised in polygenic risk scores (PRS), the effect of common, low penetrant ...
OBJECTIVE: Colorectal cancer (CRC) has a substantial heritable component. Common genetic variation h...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P -8) associate...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8) a...
BackgroundPrevious genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) ...
Purpose This study investigated the utility of modeling modifiable lifestyle risk factors in additio...
Purpose: To date, genomewide association studies have identified 10 genetic loci associated with col...
Colorectal cancer (CRC) screening of the average risk population is only indicated according to age....
Colorectal cancer (CRC) screening of the average risk population is only indicated a...
Colorectal cancer (CRC) is the third most common global cancer. Approximately one fifth of phenotypi...
Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence...
Background & AimsEarly-onset colorectal cancer (CRC, in persons younger than 50 years old) is increa...
In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we...
Genome-wide association studies have been successful in elucidating the genetic basis of colorectal ...