Keratinocytes are central to the barrier functions of surface epithelia, such as the gingiva and epidermis. RIPK4 is a key regulator of keratinocyte differentiation; however, the signalling pathways in which it functions remain poorly defined. In this study, we identified a regulatory relationship between RIPK4 and ELF3, an ETS family transcription factor. RIPK4 was shown to be important for the upregulation of ELF3 gene expression by the PKC agonist PMA in both oral and epidermal keratinocytes. RIPK4 promotes keratinocyte differentiation in part by phosphorylating and thereby activating the IRF6 transcription factor. Significantly, silencing of IRF6 inhibited the PMA-inducible expression of ELF3. A role for the GRHL3 transcription factor, ...
In humans, receptor-interacting protein kinase 4 (RIPK4) mutations can lead to the autosomal recessi...
The receptor-interacting protein kinase 4 (RIPK4) plays an important role in the development and mai...
Contains fulltext : 144891.pdf (Publisher’s version ) (Open Access)The transcripti...
© 2015 Dr. Mei Qi KwaStratified squamous epithelia, such as those that line the oral cavity and skin...
RIPK4 is a key player in epidermal differentiation and barrier formation. RIPK4 signaling pathways c...
RIPK4 is a key player in epidermal differentiation and barrier formation. RIPK4 signaling pathways c...
Epidermal development and maintenance are finely regulated events requiring a strict balance between...
Receptor-interacting protein kinase 4 (RIPK4) and interferon regulatory factor 6 (IRF6) are critical...
AbstractThe epidermis is a stratified, continually renewing epithelium dependent on a balance among ...
The receptor-interacting protein (RIP) family kinase RIP4 interacts with protein kinase C (PKC) isof...
We recently demonstrated that the expression of the interferon regulatory factor 6 (IRF6) transcript...
The receptor interacting protein kinases (RIPK) are a family of serine/threonine kinases that are in...
Receptor-interacting proteins (RIPs) are important regulators of cell proliferation and differentiat...
As epithelial tissues, the cornea epithelium and epidermis share many functional, morphological and ...
Receptor-interacting serine/threonine protein kinase 4 (RIPK4) and its kinase substrate the transcri...
In humans, receptor-interacting protein kinase 4 (RIPK4) mutations can lead to the autosomal recessi...
The receptor-interacting protein kinase 4 (RIPK4) plays an important role in the development and mai...
Contains fulltext : 144891.pdf (Publisher’s version ) (Open Access)The transcripti...
© 2015 Dr. Mei Qi KwaStratified squamous epithelia, such as those that line the oral cavity and skin...
RIPK4 is a key player in epidermal differentiation and barrier formation. RIPK4 signaling pathways c...
RIPK4 is a key player in epidermal differentiation and barrier formation. RIPK4 signaling pathways c...
Epidermal development and maintenance are finely regulated events requiring a strict balance between...
Receptor-interacting protein kinase 4 (RIPK4) and interferon regulatory factor 6 (IRF6) are critical...
AbstractThe epidermis is a stratified, continually renewing epithelium dependent on a balance among ...
The receptor-interacting protein (RIP) family kinase RIP4 interacts with protein kinase C (PKC) isof...
We recently demonstrated that the expression of the interferon regulatory factor 6 (IRF6) transcript...
The receptor interacting protein kinases (RIPK) are a family of serine/threonine kinases that are in...
Receptor-interacting proteins (RIPs) are important regulators of cell proliferation and differentiat...
As epithelial tissues, the cornea epithelium and epidermis share many functional, morphological and ...
Receptor-interacting serine/threonine protein kinase 4 (RIPK4) and its kinase substrate the transcri...
In humans, receptor-interacting protein kinase 4 (RIPK4) mutations can lead to the autosomal recessi...
The receptor-interacting protein kinase 4 (RIPK4) plays an important role in the development and mai...
Contains fulltext : 144891.pdf (Publisher’s version ) (Open Access)The transcripti...