Fulltext embargoed for: 12 months post date of publicationThe dysregulation of PI3K/AKT/mTORC1 signalling and/or hyperactivation of MYC are observed in a high proportion of human cancers, and together they form a 'super signalling' network mediating malignancy. A fundamental downstream action of this signalling network is up-regulation of ribosome biogenesis and subsequent alterations in the patterns of translation and increased protein synthesis, which are thought to be critical for AKT/MYC-driven oncogenesis. We have demonstrated that AKT and MYC cooperate to drive ribosomal DNA (rDNA) transcription and ribosome biogenesis, with AKT being essential for rDNA transcription and in vitro survival of lymphoma cells isolated from a MYC-driven m...
mTOR complex1, the major regulator of mRNA translation in all eukaryotic cells, is strongly activate...
Increased expression and activity of the MYC protein is a widespread cancer hallmark and renders tum...
The serine / threonine kinases, Akt1/PKB, Akt2/PKB, and Akt3 /PKB, play a critical role in preventin...
The dysregulation of PI3K/AKT/mTORC1 signalling and/or hyperactivation of MYC are observed in a high...
© 2014 Dr. Jennifer Rose DevlinThe growth and proliferation of both normal and malignant cells is de...
UNLABELLED Ribosome biogenesis and protein synthesis are dysregulated in many cancers, with those dr...
Fulltext embargoed for: 12 months post date of publicationUNLABELLED: MYC deregulation is common in ...
© 2011 Dr. Megan Julie BywaterElevated rates of ribosomal RNA (rRNA) synthesis have long been consid...
The AKT signalling pathway is a major regulator of protein synthesis that impinges on multiple cellu...
© 2018 Dr. Eric Purwadinata KusnadiRecent studies by our group and others have demonstrated that onc...
The AKT signalling pathway is a major regulator of protein synthesis that impinges on multiple cellu...
The Myc oncogene regulates the expression of several components of the protein synthetic machinery, ...
Increased rates of ribosome biogenesis and biomass accumulation are fundamental properties of rapidl...
Fulltext embargoed for: 12 months post date of publicationNeoplastic transformation requires the eli...
A variety of mechanisms confer hypersensitivity of tumor cells to the macrolide rapamycin, the proto...
mTOR complex1, the major regulator of mRNA translation in all eukaryotic cells, is strongly activate...
Increased expression and activity of the MYC protein is a widespread cancer hallmark and renders tum...
The serine / threonine kinases, Akt1/PKB, Akt2/PKB, and Akt3 /PKB, play a critical role in preventin...
The dysregulation of PI3K/AKT/mTORC1 signalling and/or hyperactivation of MYC are observed in a high...
© 2014 Dr. Jennifer Rose DevlinThe growth and proliferation of both normal and malignant cells is de...
UNLABELLED Ribosome biogenesis and protein synthesis are dysregulated in many cancers, with those dr...
Fulltext embargoed for: 12 months post date of publicationUNLABELLED: MYC deregulation is common in ...
© 2011 Dr. Megan Julie BywaterElevated rates of ribosomal RNA (rRNA) synthesis have long been consid...
The AKT signalling pathway is a major regulator of protein synthesis that impinges on multiple cellu...
© 2018 Dr. Eric Purwadinata KusnadiRecent studies by our group and others have demonstrated that onc...
The AKT signalling pathway is a major regulator of protein synthesis that impinges on multiple cellu...
The Myc oncogene regulates the expression of several components of the protein synthetic machinery, ...
Increased rates of ribosome biogenesis and biomass accumulation are fundamental properties of rapidl...
Fulltext embargoed for: 12 months post date of publicationNeoplastic transformation requires the eli...
A variety of mechanisms confer hypersensitivity of tumor cells to the macrolide rapamycin, the proto...
mTOR complex1, the major regulator of mRNA translation in all eukaryotic cells, is strongly activate...
Increased expression and activity of the MYC protein is a widespread cancer hallmark and renders tum...
The serine / threonine kinases, Akt1/PKB, Akt2/PKB, and Akt3 /PKB, play a critical role in preventin...