© 2011 Dr. Andrea NewboldThe opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs) play important roles in tightly regulating gene expression through regulated chromatin remodelling. It is now well-established that alterations in epigenetic regulation are commonplace in haematological malignancies and solid tumours and HDACs have been identifi ed as promising therapeutic targets for the reversal of aberrant epigenetic states associated with cancer. Structurally diverse HDAC inhibitors (HDACi) have been developed that can bind to HDACs, inhibit their enzymatic activity and induce histone acetylation. In addition to the acetylation of histones, HDACi can also cause the acetylation of non-histone proteins wh...
Histone deacetylase inhibitors (HDACi) are a promising new class of chemotherapeutic drug currently ...
Today, we are witnessing an explosion of scientific concepts in cancer chemotherapy. It has been con...
Histone deacetylases (HDACs) regulate transcription and specific functions, such as tumor suppressio...
Background. Despite recent success toward discovery of more effective anticancer drugs, chemoresista...
Genetic abnormalities have been conventionally considered as hallmarks of cancer. However, studies o...
Influencing epigenetic tumorigenic modifications is an exciting strategy for anticancer drug develop...
Influencing epigenetic tumorigenic modifications is an exciting strategy for anticancer drug develop...
Post translational modification of histones and non-histone proteins by acetylation play a key role ...
Uncontrolled cell proliferation and resistance to apoptosis in cancer are, among others, regulated b...
Uncontrolled cell proliferation and resistance to apoptosis in cancer are, among others, regulated b...
Histone deacetylase inhibitors (HDACi) are anticancer agents that induce hyperacetylation of histone...
Post translational modification of histones and non-histone proteins by acetylation play a key role ...
Uncontrolled cell proliferation and resistance to apoptosis in cancer are, among others, regulated b...
Uncontrolled cell proliferation and resistance to apoptosis in cancer are, among others, regulated b...
Carcinogenesis cannot be explained only by genetic alterations, but also involves epigenetic process...
Histone deacetylase inhibitors (HDACi) are a promising new class of chemotherapeutic drug currently ...
Today, we are witnessing an explosion of scientific concepts in cancer chemotherapy. It has been con...
Histone deacetylases (HDACs) regulate transcription and specific functions, such as tumor suppressio...
Background. Despite recent success toward discovery of more effective anticancer drugs, chemoresista...
Genetic abnormalities have been conventionally considered as hallmarks of cancer. However, studies o...
Influencing epigenetic tumorigenic modifications is an exciting strategy for anticancer drug develop...
Influencing epigenetic tumorigenic modifications is an exciting strategy for anticancer drug develop...
Post translational modification of histones and non-histone proteins by acetylation play a key role ...
Uncontrolled cell proliferation and resistance to apoptosis in cancer are, among others, regulated b...
Uncontrolled cell proliferation and resistance to apoptosis in cancer are, among others, regulated b...
Histone deacetylase inhibitors (HDACi) are anticancer agents that induce hyperacetylation of histone...
Post translational modification of histones and non-histone proteins by acetylation play a key role ...
Uncontrolled cell proliferation and resistance to apoptosis in cancer are, among others, regulated b...
Uncontrolled cell proliferation and resistance to apoptosis in cancer are, among others, regulated b...
Carcinogenesis cannot be explained only by genetic alterations, but also involves epigenetic process...
Histone deacetylase inhibitors (HDACi) are a promising new class of chemotherapeutic drug currently ...
Today, we are witnessing an explosion of scientific concepts in cancer chemotherapy. It has been con...
Histone deacetylases (HDACs) regulate transcription and specific functions, such as tumor suppressio...