Efficiency of Pleurotus florida dietary supplement in reducing Cadmium toxicity in Albino Rat (Rattus norvegicus)

Pleurotus florida was investigated to reduce cadmium toxicity via haematological and histopathological analysis in Wistar albino rats. A total number of 28 Rattus norvegicus were divided into 7 groups (2 male and 2 female) different feeding concentration of cadmium and mushroom. Clinical signs observed during the 16days dosing period include loss of appetite, weight loss, diarrhoea, sluggishness and coughing, for the treated groups (B -G). Haematology results showed that there were significant differences (p0.05) in RBC, MCV, MPV, LY and Hgb of the treated groups. The histopathological alterations in sleep were time and sex dependent ranging from slightly atrophied follicle to moderate atrophied follicle in both male and female rat, but more severe in female. Abatement of Cadmium toxicity from this experiment using P. florida was successful although was dependent on the concentration of the exposed metal