PENGARUH PEMBERIAN EKSTRAK DAUN LIDAH MERTUA (Sansevieria trifasciata var. laurentii) TERHADAP DEGENERASI HIDROPIK PADA HEPAR TIKUS (Rattus norvegicus strain wistar) YANG DIINDUKSI TIMBAL PER-ORAL

Background : Liver injuries could happen to everyone. Increasing of ROS by lead can cause liver injuries and hydropic degeneration is an early sign of liver injuries. Snake plant contains vitamin C,leucine, glutamate, and flavonoid that expected to inhibit the free radicals effects caused by lead. Objective : To find the effect of Snake Plant extract towards the amount of hydropic degeneration in oral lead-induced white rats liver Methods:True experimental with post test only control group design, 20 rats were divided to 4 groups, K+ was given 26mg/200grBW/day lead induction, P1;P2;P3 was given lead induction and 20;40;80 (mg/200grBW/day) of Snake Plant extract, then rats liver were prepared with H&E stain and observed with microscope. Results and Discussion:One-way ANOVA test showed significant difference (p=0,003), Post-Hoc Bonferroni showed significant difference between control group and group with 80 mg/grBW/day of Snake Plant extract (p=0,003), linear regression test obtained AR Square : 0,581 (the Snake Plant extract had 58,1 % effect on hydropic degeneration). The decreasing of hydropic degeneration was caused by vitamin C, leucine, glutamate, and flavonoid that inhibited free radicals. Conclusion: Snake Plant extract had an effect on decreasing the amount of hydropic degeneration in white rats