Abstract Background/Aims: The permeability transition pore (PTP) is an unselective, Ca2+-dependent high conductance channel of the inner mitochondrial membrane whose molecular identity has long remained a mystery. The most recent hypothesis is that pore formation involves the F-ATP synthase, which consistently generates Ca2+-activated channels. Available structures do not display obvious features that can accommodate a channel; thus, how the pore can form and whether its activity can be entirely assigned to F-ATP synthase is the matter of debate. In this study, we investigated the role of F-ATP synthase subunits e, g and b in PTP formation. Methods: Yeast null mutants for e, g and the first transmembrane (TM) a-helix o...
Purified F-ATP synthase dimers of yeast mitochondria display Ca2+-dependent channel activity with pr...
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in ...
The f subunit is localized at the base of the ATP synthase peripheral stalk. Its function in the hum...
Background/Aims: The permeability transition pore (PTP) is an unselective, Ca2+-dependent high cond...
Background/Aims: The permeability transition pore (PTP) is an unselective, Ca2+-dependent high condu...
Background/Aims: The permeability transition pore (PTP) is an unselective, Ca 2+ -dependent high con...
Background/Aims: The permeability transition pore (PTP) is an unselective, Ca 2+ -dependent high con...
Background/Aims: The permeability transition pore (PTP) is an unselective, Ca2+-dependent high condu...
The Permeability transition pore (PTP) is a mitochondrial channel the opening of which induces cell ...
The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a ...
Purified F-ATP synthase dimers of yeast mitochondria display Ca(2+)-dependent channel activity with ...
Purified F-ATP synthase dimers of yeast mitochondria display Ca 2+-dependent channel activity with p...
Purified F-ATP synthase dimers of yeast mitochondria display Ca 2+-dependent channel activity with p...
F-ATP synthase is a leading candidate as the mitochondrial permeability transition pore (PTP) but t...
F-ATP synthase is a leading candidate as the mitochondrial permeability transition pore (PTP) but t...
Purified F-ATP synthase dimers of yeast mitochondria display Ca2+-dependent channel activity with pr...
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in ...
The f subunit is localized at the base of the ATP synthase peripheral stalk. Its function in the hum...
Background/Aims: The permeability transition pore (PTP) is an unselective, Ca2+-dependent high cond...
Background/Aims: The permeability transition pore (PTP) is an unselective, Ca2+-dependent high condu...
Background/Aims: The permeability transition pore (PTP) is an unselective, Ca 2+ -dependent high con...
Background/Aims: The permeability transition pore (PTP) is an unselective, Ca 2+ -dependent high con...
Background/Aims: The permeability transition pore (PTP) is an unselective, Ca2+-dependent high condu...
The Permeability transition pore (PTP) is a mitochondrial channel the opening of which induces cell ...
The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a ...
Purified F-ATP synthase dimers of yeast mitochondria display Ca(2+)-dependent channel activity with ...
Purified F-ATP synthase dimers of yeast mitochondria display Ca 2+-dependent channel activity with p...
Purified F-ATP synthase dimers of yeast mitochondria display Ca 2+-dependent channel activity with p...
F-ATP synthase is a leading candidate as the mitochondrial permeability transition pore (PTP) but t...
F-ATP synthase is a leading candidate as the mitochondrial permeability transition pore (PTP) but t...
Purified F-ATP synthase dimers of yeast mitochondria display Ca2+-dependent channel activity with pr...
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in ...
The f subunit is localized at the base of the ATP synthase peripheral stalk. Its function in the hum...