Human peroxidasin 1 promotes angiogenesis through ERK1/2, Akt and FAK pathways.
- Medfai, Hayfa
- Khalil, Alia
- Rousseau, Alexandre
- Nuyens, Vincent
- Paumann-Page, Martina
- Sevcnikar, Benjamin
- Furtmüller, Paul G
- Obinger, Christian
- Moguilevsky, Nicole
- Peulen, Olivier
- Herfs, Michael
- Castronovo, V.
- Amri, Mohamed
- Van Antwerpen, Pierre
- Vanhamme, Luc
- Zouaoui Boudjeltia, Karim
Publication date
July 2018
DOI Publisher
Oxford University Press (OUP) ISSN
0008-6363Abstract
The term angiogenesis refers to sprouting of new blood vessels from pre-existing ones. The angiogenic process involves cell migration and tubulogenesis requiring interaction between endothelial cells and the extracellular matrix. Human peroxidasin 1 (hsPxd01) is a multidomain heme peroxidase found embedded in the basement membranes. As it promotes the stabilization of extracellular matrix, we investigated its possible role in angiogenesis both in vitro and in vivo.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
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