We wish to thank the Dundee Drug Discovery Unit for access to the diversity set library and the European Synchrotron Radiation Facility, Grenoble, for time at the beamline. This work was supported by a Grant (G0900138) and a Wellcome Trust Senior Research Fellowship (WT087590MA) to D.M.F.v.A. D.E.A.L. is the recipient of a MRC Clinical Research Training Fellowship (G1100430). The structures have been deposited in the Protein Data Bank with accession codes 4TX6 and 4TXE.Peer reviewedPublisher PD
Chitinases represent an alternative therapeutic target for opportunistic invasive mycosis since they...
International audience: Chitin synthases polymerize UDP-GlcNAC to form chitin polymer, a key compone...
Chitinase is necessary for fungal growth and cell division and, therefore, is an ideal target for th...
AbstractA limited therapeutic arsenal against increasing clinical disease due to Aspergillus spp. ne...
A limited therapeutic arsenal against increasing clinical disease due to Aspergillus spp. necessitat...
Chitin is an essential structural component of the fungal cell wall. Chitinases are thought to be im...
Acknowledgements We wish to thank the Dundee Drug Discovery Unit for access to the Fragment library ...
SummaryChitinases hydrolyse the β(1,4)-glycosidic bonds of chitin, an essential fungal cell wall com...
SummaryNatural products are often large, synthetically intractable molecules, yet frequently offer s...
Chitinase proteins are expressed in most of reigns, from fungi to mammals. This kind of proteins can...
Inhibition of glycosylhydrolases by peptides mimicking carbohydrates opens a new field in antifungal...
Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. S...
Aspergillus fumigatus, the leading cause of invasive aspergillosis, has been recognised as a priorit...
Chitinases represent an alternative therapeutic target for opportunistic invasive mycosis since they...
International audience: Chitin synthases polymerize UDP-GlcNAC to form chitin polymer, a key compone...
Chitinase is necessary for fungal growth and cell division and, therefore, is an ideal target for th...
AbstractA limited therapeutic arsenal against increasing clinical disease due to Aspergillus spp. ne...
A limited therapeutic arsenal against increasing clinical disease due to Aspergillus spp. necessitat...
Chitin is an essential structural component of the fungal cell wall. Chitinases are thought to be im...
Acknowledgements We wish to thank the Dundee Drug Discovery Unit for access to the Fragment library ...
SummaryChitinases hydrolyse the β(1,4)-glycosidic bonds of chitin, an essential fungal cell wall com...
SummaryNatural products are often large, synthetically intractable molecules, yet frequently offer s...
Chitinase proteins are expressed in most of reigns, from fungi to mammals. This kind of proteins can...
Inhibition of glycosylhydrolases by peptides mimicking carbohydrates opens a new field in antifungal...
Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. S...
Aspergillus fumigatus, the leading cause of invasive aspergillosis, has been recognised as a priorit...
Chitinases represent an alternative therapeutic target for opportunistic invasive mycosis since they...
International audience: Chitin synthases polymerize UDP-GlcNAC to form chitin polymer, a key compone...
Chitinase is necessary for fungal growth and cell division and, therefore, is an ideal target for th...