The human T-cell leukemia virus type 1 (HTLV-1) Tax transactivator is known to induce or repress various cellular genes, several of them encoding transcription factors. As Tax is known to deregulate various basic bHLH factors, we looked more specifically at its effect on TAL1 (T-cell acute lymphoblastic leukemia 1), also known as SCL (stem cell leukemia). Indeed, TAL1 is deregulated in a high percentage of T-cell acute lymphoblastic leukemia cells, and its oncogenic properties are well-established. Here we show that Tax induces transcription of this proto-oncogene by stimulating the activity of the TAL1 gene promoter 1b, through both the CREB and NF-κB pathways. It was also observed that TAL1 upregulates HTLV-1 promoter activity, in either ...
Human T-cell leukemia virus type 1 (HTLV-1) is a human retrovirus that causes adult T-cell leukemia ...
The human T cell leukemia virus type I (HTLV-I) is the etiological agent of adult T cell leukemia. T...
Human T-cell leukemia virus type I (HTLV-I)1 causes adult T-cell leukemia (ATL) (1\u20133). The viru...
The human T-cell leukemia virus type I or HTLV-I is the causative agent of adult T-cell leukemia. A ...
Tax, an oncoprotein virally expressed from Human T-cell Leukemia Virus (HTLV), is a transcriptional ...
AbstractThe oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) is a potent transactivato...
Human T cell leukemia virus type I (HTLV-I) has been identified as the etiologic agent of adult T ce...
Human T-Cell leukemia virus type I (HTLV-I) is a human retrovirus that is associated with the develo...
Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, th...
Adult T-cell leukemia (ATL) is one of the primary diseases caused by Human T-cell Leukemia Virus typ...
virus type 1 (HTLV-1) oncoprotein Tax is correlated with cellular transformation, contributing to th...
The X region of human T-cell leukemia virus type I (HTLV-I) encodes two proteins that regulate viral...
The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is a potent activator of viral transc...
Crosstalk between expression of the HTLV-1 Tax transactivator and the oncogenic bHLH transcription f...
Human T-cell leukemia virus type 1 (HTLV-1), the first human retrovirus discovered, is the etiologic...
Human T-cell leukemia virus type 1 (HTLV-1) is a human retrovirus that causes adult T-cell leukemia ...
The human T cell leukemia virus type I (HTLV-I) is the etiological agent of adult T cell leukemia. T...
Human T-cell leukemia virus type I (HTLV-I)1 causes adult T-cell leukemia (ATL) (1\u20133). The viru...
The human T-cell leukemia virus type I or HTLV-I is the causative agent of adult T-cell leukemia. A ...
Tax, an oncoprotein virally expressed from Human T-cell Leukemia Virus (HTLV), is a transcriptional ...
AbstractThe oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) is a potent transactivato...
Human T cell leukemia virus type I (HTLV-I) has been identified as the etiologic agent of adult T ce...
Human T-Cell leukemia virus type I (HTLV-I) is a human retrovirus that is associated with the develo...
Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, th...
Adult T-cell leukemia (ATL) is one of the primary diseases caused by Human T-cell Leukemia Virus typ...
virus type 1 (HTLV-1) oncoprotein Tax is correlated with cellular transformation, contributing to th...
The X region of human T-cell leukemia virus type I (HTLV-I) encodes two proteins that regulate viral...
The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is a potent activator of viral transc...
Crosstalk between expression of the HTLV-1 Tax transactivator and the oncogenic bHLH transcription f...
Human T-cell leukemia virus type 1 (HTLV-1), the first human retrovirus discovered, is the etiologic...
Human T-cell leukemia virus type 1 (HTLV-1) is a human retrovirus that causes adult T-cell leukemia ...
The human T cell leukemia virus type I (HTLV-I) is the etiological agent of adult T cell leukemia. T...
Human T-cell leukemia virus type I (HTLV-I)1 causes adult T-cell leukemia (ATL) (1\u20133). The viru...