Bioengineered Fascicle-Like Skeletal Muscle Tissue Constructs

Tissue engineered skeletal muscle constructs have and will continue to be valuable in treating, and testing various muscle injuries and diseases. However a significant drawback to numerous methods of producing 3D skeletal muscle constructs grown in vitro is that muscle cell density as a fraction of total volume or mass, is often significantly lower than muscle found in vivo. Therefore a method to increase muscle cell density within a construct is needed. Topics: Biological tissues, MuscleNational Science Foundation (U.S.). Center on Emergent Behaviors of Integrated Cellular Systems (Grant CBET-0939511