Techniques for the prognostication of coma outcomes after cardiac arrest

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.Cataloged from PDF version of thesis.Includes bibliographical references (pages 120-134).Electroencephalography (EEG) features are known to predict neurological outcomes of patients in coma after cardiac arrest, but the association between EEG features and outcomes is time-dependent. Recent advances in machine learning allow temporally-dependent features to be learned from the EEG waveforms in a fully-automated way, allowing for faster, better-calibrated and more reliable prognostic predictions. In this thesis, we discuss three major contributions to the problem of coma prognostication after cardiac arrest: (1) the collection of the world's largest multi-center EEG database for patients in coma after cardiac arrest, (2) the development of time-dependent, interpretable, feature-based EEG models that may be used for both risk-scoring and decision support at the bedside, and (3) a careful comparison of the performance and utility of feature-based techniques to that of representation learning models that fully-automate the extraction of time-dependent features for outcome prognostication.by Mohammad Mahdi Ghassemi.Ph. D