Inflammatory bowel disease (IBD) is a chronic condition driven by loss of homeostasis between the mucosal immune system, the commensal gut microbiota, and the intestinal epithelium. Our goal is to understand how these components of the intestinal ecosystem cooperate to control homeostasis. By combining quantitative measures of epithelial hyperplasia and immune infiltration with multivariate analysis of inter- and intracellular signaling, we identified epithelial mammalian target of rapamycin (mTOR) signaling as a potential driver of inflammation in a mouse model of colitis. A kinetic analysis of mTOR inhibition revealed that the pathway regulates epithelial differentiation, which in turn controls the cytokine milieu of the colon. Consistent...
The mammalian intestine harbors an estimated 100 trillion microorganisms, which normally maintain a ...
Crohn’s disease (CD) patients can be grouped into patients suffering from ileitis, ileocolitis, jeju...
BACKGROUND: Epithelial barrier disturbance is thought to contribute to the pathogenesis of inflammat...
<div><p>Inflammatory bowel disease (IBD) is a chronic condition driven by loss of homeostasis betwee...
Inflammatory bowel disease (IBD) is a chronic condition driven by loss of homeostasis between the mu...
Interactions between the epithelium and the immune system are critical in the pathogenesis of inflam...
Background— The pathogenesis of inflammatory bowel disease (IBD) is complex and the need to identify...
The healthy human colonic epithelium (hCE) is exposed to luminal contents from digested meals, inges...
The global incidence of inflammatory bowel disease (IBD) has increased rapidly in recent years, but ...
Background: The human colon harbours a plethora of bacteria known to broadly impact on mucosal metab...
<p>Interactions among the gut microbiome, dysregulated immune responses, and genetic factors contrib...
Background: The early molecular changes preceding the onset of mucosal inflammation in colitis and t...
The exact pathophysiology of inflammatory bowel disease (IBD) is still unknown. However, over the ye...
The intestine serves as both our largest single barrier to the external environment and the host of ...
The intestinal epithelial monolayer, at the boundary between microbes and the host immune system, pl...
The mammalian intestine harbors an estimated 100 trillion microorganisms, which normally maintain a ...
Crohn’s disease (CD) patients can be grouped into patients suffering from ileitis, ileocolitis, jeju...
BACKGROUND: Epithelial barrier disturbance is thought to contribute to the pathogenesis of inflammat...
<div><p>Inflammatory bowel disease (IBD) is a chronic condition driven by loss of homeostasis betwee...
Inflammatory bowel disease (IBD) is a chronic condition driven by loss of homeostasis between the mu...
Interactions between the epithelium and the immune system are critical in the pathogenesis of inflam...
Background— The pathogenesis of inflammatory bowel disease (IBD) is complex and the need to identify...
The healthy human colonic epithelium (hCE) is exposed to luminal contents from digested meals, inges...
The global incidence of inflammatory bowel disease (IBD) has increased rapidly in recent years, but ...
Background: The human colon harbours a plethora of bacteria known to broadly impact on mucosal metab...
<p>Interactions among the gut microbiome, dysregulated immune responses, and genetic factors contrib...
Background: The early molecular changes preceding the onset of mucosal inflammation in colitis and t...
The exact pathophysiology of inflammatory bowel disease (IBD) is still unknown. However, over the ye...
The intestine serves as both our largest single barrier to the external environment and the host of ...
The intestinal epithelial monolayer, at the boundary between microbes and the host immune system, pl...
The mammalian intestine harbors an estimated 100 trillion microorganisms, which normally maintain a ...
Crohn’s disease (CD) patients can be grouped into patients suffering from ileitis, ileocolitis, jeju...
BACKGROUND: Epithelial barrier disturbance is thought to contribute to the pathogenesis of inflammat...