Resolving CNS mRNA Heterogeneity: Examining mRNA Alternative Polyadenylation at a Cell-Type-Specific Level

Alternative polyadenylation often regulates mRNA isoform usage. In this issue of Neuron, Hwang et al. (2017) describe a powerful new cell-type-specific methodology, cTag-PAPERCLIP, which can be used to study alternative polyadenylation in the CNS. Keywords: alternative polyadenylation; cell type specificity; cTag-PAPERCLI