Neither branded nor generic lopinavir/ritonavir produces adequate lopinavir concentrations at a reduced dose of 200/50 mg twice daily.
- Ramautarsing, R.A.
- Lugt, J. van der
- Gorowara, M.
- Wongsabut, J.
- Khongpetch, C.
- Phanuphak, P.
- Ananworanich, J.
- Lange, J.M.A.
- Burger, D.M.
- Ruxrungtham, K.
- Avihingsanon, A.
DOIAbstract
Item does not contain fulltextWe assessed pharmacokinetic (PK) parameters of reduced dose lopinavir/ritonavir (LPV/r) and compared generic and branded tablets. Twenty HIV-infected patients using protease inhibitors with HIV RNA <50 copies per milliliter were randomized to generic or branded LPV/r 200/50mg twice daily (BID). At week 2, PK-sampling was performed. Patients crossed over to the other arm until week 12, with another PK-sampling at week 4. Subtherapeutic lopinavir concentrations were observed in 10/40 samples. PK parameters were comparable between branded and generic tablets. All patients remained virologically suppressed at week 12. In conclusion, LPV/r 200/50mg BID does not lead to adequate lopinavir plasma concentrations. Gener...
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