Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure

Van Tassell, B.W.
Arena, R.A.
Toldo, S.
Mezzaroma, E.
Azam, T.
Seropian, I.M.
Shah, K.
Canada, J.
Voelkel, N.F.
Dinarello, C.A.
Abbate, A.

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Publication date

January 2012

DOI

10.1371/journal.pone.0033438

Publisher

Public Library of Science (PLoS)

ISSN

1932-6203

Citation count (estimate)

Abstract

Contains fulltext : 107753.pdf (publisher's version ) (Open Access)BACKGROUND: Heart failure (HF) is a complex clinical syndrome characterized by impaired cardiac function and poor exercise tolerance. Enhanced inflammation is associated with worsening outcomes in HF patients and may play a direct role in disease progression. Interleukin-1beta (IL-1beta) is a pro-inflammatory cytokine that becomes chronically elevated in HF and exerts putative negative inotropic effects. METHODS AND RESULTS: We developed a model of IL-1beta-induced left ventricular (LV) dysfunction in healthy mice that exhibited a 32% reduction in LV fractional shortening (P<0.001) and a 76% reduction in isoproterenol response (P<0.01) at 4 hours following ...