Effect of processing techniques on new poly(ε-caprolactone)-embelin microparticles of biomedical interest
- Cortez Tornello, Pablo Roberto
- Feresin, Gabriela Egly
- Tapia, Alejandro
- Dzieciuch, Monika
- Cuadrado, Teresita Raquel
- Abraham, Gustavo Abel
DOIAbstract
Poly(ε-caprolactone) microparticles containing embelin (PCLE) are prepared by electrohydrodynamic atomization (EHDA) and emulsion-solvent evaporation techniques. Microparticles are characterized in terms of drug state, drug-loading capacity, encapsulation efficiency, morphology and in vitro release in different mediums. Physicochemical, morphological, and thermal characterization is presented. Kinetic analysis is performed. EHDA microparticles present higher size, surface area, and encapsulation efficiency. The release profiles combine a high initial release, followed by a slow-controlled release stage. Electrosprayed PCLE presented characteristics such as size (3.14 ± 0.05 μm), zeta potential (−49.22 ± 2.88 mV) and release profiles that co...
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