Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
- Purdue, M.P.
- Johansson, M.
- Zelenika, D.
- Toro, J.R.
- Scelo, G.
- Moore, L.E.
- Prokhortchouk, E.
- Wu, X.
- Kiemeney, L.A.L.M.
- Gaborieau, V.
- Jacobs, K.B.
- Chow, W.H.
- Zaridze, D.
- Matveev, V.
- Lubinski, J.
- Trubicka, J.
- Szeszenia-Dabrowska, N.
- Lissowska, J.
- Rudnai, P.
- Fabianova, E.
- Bucur, A.
- Bencko, V.
- Foretova, L.
- Janout, V.
- Boffetta, P.
- Colt, J.S.
- Davis, F.G.
- Schwartz, K.L.
- Banks, R.E.
- Selby, P.J.
- Harnden, P.
- Berg, C.D.
- Hsing, A.W.
- Grubb, R.L. 3rd
- Boeing, H.
- Vineis, P.
- Clavel-Chapelon, F.
- Palli, D.
- Tumino, R.
- Krogh, V.
- Panico, S.
- Duell, E.J.
- Quiros, J.R.
- Sanchez, M.J.
- Navarro, C
- Ardanaz, E.
- Dorronsoro, M.
- Khaw, K.T.
- Allen, N.E.
- Bueno-De-Mesquita, H.B.
- Peeters, P.H.M.
- Trichopoulos, D.
- Linseisen, J.
- Ljungberg, B
- Overvad, K.
- Tjonneland, A.
- Romieu, I.
- Riboli, E.
- Mukeria, A.
- Shangina, O.
- Stevens, V.L.
- Thun, M.J.
- Diver, W.R.
- Gapstur, S.M.
- Pharoah, P.D.
- Easton, D.F.
- Albanes, D.
- Weinstein, S.J.
- Virtamo, J.
- Vatten, L.
- Hveem, K.
- Njolstad, I.
- Tell, G.S.
- Stoltenberg, C.
- Kumar, R.
- Koppova, K.
- Cussenot, O.
- Benhamou, S.
- Oosterwijk, E.
- Vermeulen, H.H.M.
- Aben, K.K.H.
- Marel, S.L. van der
- Ye, Y.
- Wood, C.G.
- Pu, X.
- Mazur, A.M.
- Boulygina, E.S.
- Chekanov, N.N.
- Foglio, M.
- Lechner, D.
- Gut, I
- Heath, S.
- Blanche, H.
- Hutchinson, A.
- Thomas, G.
- Wang, Z.
- Yeager, M.
- Fraumeni, J.F. Jr.
- Skryabin, K.G.
- McKay, J.D.
DOIAbstract
Contains fulltext : 97937.pdf (publisher's version ) (Closed access)We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r(2) = 0.99 in controls), rs11894252 (P = 1.8 x 10) and rs7579899 (P = 2.3 x 10), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no c...
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