European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene
- Rafnar, T.
- Vermeulen, H.H.M.
- Sulem, P.
- Thorleifsson, G.
- Aben, K.K.H.
- Witjes, J.A.
- Grotenhuis, A.J.
- Verhaegh, G.W.C.T.
- Hulsbergen-van de Kaa, C.A.
- Besenbacher, S.
- Gudbjartsson, D.
- Stacey, S.N.
- Gudmundsson, J.
- Johannsdottir, H.
- Bjarnason, H.
- Zanon, C.
- Helgadottir, H.
- Jonasson, J.G.
- Tryggvadottir, L.
- Jonsson, E.
- Geirsson, G.
- Nikulasson, S.
- Petursdottir, V.
- Bishop, D.T.
- Chung-Sak, S.
- Choudhury, A.
- Elliott, F.
- Barrett, J.H.
- Knowles, M.A.
- Verdier, P. de
- Ryk, C.
- Lindblom, A.
- Rudnai, P.
- Gurzau, E
- Koppova, K.
- Vineis, P.
- Polidoro, S.
- Guarrera, S.
- Sacerdote, C.
- Panadero, A.
- Sanz-Velez, J.I.
- Sanchez, M.
- Valdivia, G.
- Garcia-Prats, M.D.
- Hengstler, J.G.
- Selinski, S.
- Gerullis, H.
- Ovsiannikov, D.
- Khezri, A.
- Aminsharifi, A.
- Malekzadeh, M.
- Berg, L.H. van den
- Ophoff, R.A.
- Veldink, J.H.
- Zeegers, M.P.
- Kellen, E.
- Fostinelli, J.
- Andreoli, D.
- Arici, C.
- Porru, S.
- Buntinx, F.
- Ghaderi, A.
- Golka, K.
- Mayordomo, J.I.
- Matullo, G.
- Kumar, R.
- Steineck, G.
- Kiltie, A.E.
- Kong, A.
- Thorsteinsdottir, U.
- Stefansson, K.
- Kiemeney, L.A.L.M.
DOIAbstract
Contains fulltext : 97884.pdf (publisher's version ) (Closed access)Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European GWAS. The discovery sample set consisted of 1631 cases and 3822 controls from the Netherlands and 603 cases and 37 781 controls from Iceland. For follow-up, we used 3790 cases and 7507 controls from 13 sample sets of European and Iranian ancestry. Based on the discovery analysis, we followed up signals in the urea transporter (UT) gene SLC14A. The strongest signa...
Add to ORKG