Leptospira species molecular epidemiology in the genomic era

Caimi, Karina Cynthia
Repetto, Silvia
Varni, Vanina Delia
Ruybal, Paula

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Publication date

October 2017

DOI

10.1016/j.meegid.2017.08.013

Publisher

Elsevier BV

ISSN

1567-1348

Journal

Infection Genetics and Evolution

Citation count (estimate)

Abstract

Leptospirosis is a zoonotic disease which global burden is increasing often related to climatic change. Hundreds of whole genome sequences from worldwide isolates of Leptospira spp. are available nowadays, together with online tools that permit to assign MLST sequence types (STs) directly from raw sequence data. In this work we have applied R7L-MLST to near 500 genomes and strains collection globally distributed. All 10 pathogenic species as well as intermediate were typed using this MLST scheme. The correlation observed between STs and serogroups in our previous work, is still satisfied with this higher dataset sustaining the implementation of MLST to assist serological classification as a complementary approach. Bayesian phylogenetic anal...