Perivascular endfeet of astrocytes are enriched with aquaporin-4 (AQP4)—a water channel that is critically involved in water transport at the brain–blood interface and that recently was identified as a key molecule in a system for waste clearance. The factors that determine the size of the perivascular AQP4 pool remain to be identified. Here we show that the size of this pool differs considerably between brain regions, roughly mirroring regional differences in Aqp4 mRNA copy numbers. We demonstrate that a targeted deletion of α-syntrophin—a member of the dystrophin complex responsible for AQP4 anchoring—removes a substantial and fairly constant proportion (79–94 %) of the perivascular AQP4 pool across the central nervous system (CNS). Quant...
The main water channel of the brain, aquaporin-4 (AQP4), is one of the classical water-specific aqua...
Extracellular solutes in the central nervous system are exchanged between the interstitial fluid, th...
The water-permeable channel aquaporin-4 (AQP4) is highly expressed in perivascular astrocytes of the...
The water channel AQP4 is concentrated in perivascular and subpial membrane domains of brain astrocy...
Regulation of water homeostasis is a central feature of central nervous system pathophysiology. In t...
The Aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular astrocyt...
Astrocytes can functionally be defined as the true caretaker cells of the brain that provide for cel...
Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly expr...
<div><p>Aquaporin-4 (AQP4) is the primary cellular water channel in the brain and is abundantly expr...
Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the centr...
Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the centr...
Aquaporin-4 (AQP4) is the primary cellular water channel in the brain and is abundantly expressed by...
Aquaporin 4 (AQP4) is the most abundant water channel in the central nervous system (CNS). Its expre...
Aquaporin-4 (AQP4), the predominant water channel in the brain, is expressed in astrocytes and epend...
Membrane water transport is critically involved in brain volume homeostasis and in the pathogenesis ...
The main water channel of the brain, aquaporin-4 (AQP4), is one of the classical water-specific aqua...
Extracellular solutes in the central nervous system are exchanged between the interstitial fluid, th...
The water-permeable channel aquaporin-4 (AQP4) is highly expressed in perivascular astrocytes of the...
The water channel AQP4 is concentrated in perivascular and subpial membrane domains of brain astrocy...
Regulation of water homeostasis is a central feature of central nervous system pathophysiology. In t...
The Aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular astrocyt...
Astrocytes can functionally be defined as the true caretaker cells of the brain that provide for cel...
Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly expr...
<div><p>Aquaporin-4 (AQP4) is the primary cellular water channel in the brain and is abundantly expr...
Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the centr...
Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the centr...
Aquaporin-4 (AQP4) is the primary cellular water channel in the brain and is abundantly expressed by...
Aquaporin 4 (AQP4) is the most abundant water channel in the central nervous system (CNS). Its expre...
Aquaporin-4 (AQP4), the predominant water channel in the brain, is expressed in astrocytes and epend...
Membrane water transport is critically involved in brain volume homeostasis and in the pathogenesis ...
The main water channel of the brain, aquaporin-4 (AQP4), is one of the classical water-specific aqua...
Extracellular solutes in the central nervous system are exchanged between the interstitial fluid, th...
The water-permeable channel aquaporin-4 (AQP4) is highly expressed in perivascular astrocytes of the...