Androgen receptor (AR) signalling and the PI3K pathway mediate survival signals in prostate cancer, and have been shown to regulate each other by reciprocal negative feedback, such that inhibition of one activates the other. Understanding the reciprocal regulation of these pathways is important for disease management as tumour cells can adapt and survive when either single pathway is inhibited pharmacologically. We recently carried out genome-wide exon-specific profiling of prostate cancer cells to identify novel androgen-regulated transcriptional events. Here we interrogated this dataset for novel androgen-regulated genes associated with the PI3K pathway. We find that the PI3K regulatory subunits PIK3R1 (p85α) and PIK3R3 (p55γ) are direct ...
Genetic alterations that potentiate PI3K signalling are frequent in prostate cancer, yet how differe...
ArticleInflammatory processes and androgen signaling are critical for the growth of prostate cancer ...
Nuclear receptors are a superfamily of ligand-activated transcription factors that play critical rol...
Androgen receptor (AR) signalling and the PI3K pathway mediate survival signals in prostate cancer, ...
Androgen receptor (AR) signalling and the PI3K pathway mediate survival signals in prostate cancer, ...
SummaryProstate cancer is characterized by its dependence on androgen receptor (AR) and frequent act...
In 2020, an estimated 19.3 million new cancer cases were diagnosed, 7.3 % of which were cancer of ...
Background: Androgen receptor (AR) and the phosphatidylinositol-3 kinase (PI3K) signaling are two of...
Androgens regulate the physiological development of the prostate and the pathology of prostate cance...
Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B (PKB/AKT), and ma...
Prostate cancer (PCa) primarily depends on androgen receptor (AR) signaling pathway for the initiati...
In general, cancer, encompassing prostate cancer (PCa), is a disease that utilises signalling pathwa...
BACKGROUND: Androgens drive the onset and progression of prostate cancer (PCa) via androgen receptor...
Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the gold standard...
Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (...
Genetic alterations that potentiate PI3K signalling are frequent in prostate cancer, yet how differe...
ArticleInflammatory processes and androgen signaling are critical for the growth of prostate cancer ...
Nuclear receptors are a superfamily of ligand-activated transcription factors that play critical rol...
Androgen receptor (AR) signalling and the PI3K pathway mediate survival signals in prostate cancer, ...
Androgen receptor (AR) signalling and the PI3K pathway mediate survival signals in prostate cancer, ...
SummaryProstate cancer is characterized by its dependence on androgen receptor (AR) and frequent act...
In 2020, an estimated 19.3 million new cancer cases were diagnosed, 7.3 % of which were cancer of ...
Background: Androgen receptor (AR) and the phosphatidylinositol-3 kinase (PI3K) signaling are two of...
Androgens regulate the physiological development of the prostate and the pathology of prostate cance...
Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B (PKB/AKT), and ma...
Prostate cancer (PCa) primarily depends on androgen receptor (AR) signaling pathway for the initiati...
In general, cancer, encompassing prostate cancer (PCa), is a disease that utilises signalling pathwa...
BACKGROUND: Androgens drive the onset and progression of prostate cancer (PCa) via androgen receptor...
Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the gold standard...
Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (...
Genetic alterations that potentiate PI3K signalling are frequent in prostate cancer, yet how differe...
ArticleInflammatory processes and androgen signaling are critical for the growth of prostate cancer ...
Nuclear receptors are a superfamily of ligand-activated transcription factors that play critical rol...