Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators

Molecular Modeling on Structure-Function Analysis of Human Progesterone Receptor Modulators

Ria PAL

June 2011

Considering the significance of progesterone receptor (PR) modulators, the present study is explored...

Structures of acetoxy progestins (pregnane steroids)

Peterson, C. Matthew

January 1998

From C. Matthew Peterson, M.D. Progestogens, Progesterone Antagonists, Progesterone, and Androgens: ...

QSAR of progestogens: Use of a priori and computed molecular descriptors and molecular graphics

Kiralj, R
Takahata, Y
Ferreira, MMC

November 2015

Quantitative Structure-Activity Relationship (QSAR) study of two sets of oral progestogens was carri...

Molecular determinants of partial agonism by progesterone receptor modulators : implications for drug design & discovery

Lusher, S.J.

January 2013

Contains fulltext : 101060.pdf (publisher's version ) (Open Access)Radboud Univers...

X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11beta-substituted steroids.

Lusher, S.J.
Raaijmakers, H.C.A.
Vu-Pham, D.
Kazemier, B.
Bosch, R.
McGuire, R.
Azevedo, R.
Hamersma, H.
Dechering, K.
Oubrie, A.
Duin, M. van
Vlieg, J. de

January 2012

Contains fulltext : 103894.pdf (publisher's version ) (Open Access)We present here...

Sci Pharm www.scipharm.at Research article Open Access Molecular Modeling on Structure-Function Analysis of Human Progesterone Receptor Modulators

Ria Pal
Md Ataul Islam
Tabassum Hossain
Achintya Saha

August 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licen...

Progesterone receptor ligand binding domain : from conformational dynamics to drug discovery

Zheng, Liangzhen

January 2019

Hormones are vital molecules for human differentiation, development, and health. Among them, the fem...

X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11beta-substituted steroids.

Lusher, S.J.
Raaijmakers, H.C.A.
Vu-Pham, D.
Kazemier, B.
Bosch, R.
McGuire, R.
Azevedo, R.
Hamersma, H.
Dechering, K.
Oubrie, A.
Duin, M. van
Vlieg, J. de

January 2012

We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed pro...

Data_Sheet_1_Ligand Binding Induces Agonistic-Like Conformational Adaptations in Helix 12 of Progesterone Receptor Ligand Binding Domain.PDF

Liangzhen Zheng (3337176)
Kelin Xia (4825065)
Yuguang Mu (29465)

May 2019

Progesterone receptor (PR) is a member of the nuclear receptor (NR) superfamily and plays a vital ro...

The progesterone receptor. Biological effects of progestins and antiprogestins

J. F. Savouret
A. Chauchereau
M. Misrahi
P. Lescop
A. Mantel
A. Bailly

January 1994

The progesterone receptor displays the typical three-domains structure of the steroid-thyroid recept...

Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton

Yuko Nishiyama (1389555)
Shuichi Mori (362273)
Makoto Makishima (294803)
Shinya Fujii (565601)
Hiroyuki Kagechika (838715)
Yuichi Hashimoto (1665289)
Minoru Ishikawa (1665292)

June 2018

The progesterone receptor (PR) plays an important role in various physiological systems, including f...

Ligand binding induces agonistic-like conformational adaptations in helix 12 of progesterone receptor ligand binding domain

Zheng, Liangzhen
Xia, Kelin
Mu, Yuguang

January 2019

Progesterone receptor (PR) is a member of the nuclear receptor (NR) superfamily and plays a vital ro...

5-benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists

Tegley, CM
Zhi, L
Marschke, KB
Gottardis, MM
Yang, QC
Jones, TK

January 1998

A novel series of nonsteroidal progestins, 5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines (2), w...

Structural aspects of agonism and antagonism in the oestrogen receptor.

Pike, AC
Brzozowski, AM
Walton, J
Hubbard, RE
Bonn, T
Gustafsson, JA
Carlquist, M

January 2000

We have determined the three-dimensional structures of both alpha- and beta-forms of the ligand-bind...

THE MECHANISM OF RU486 ANTAGONISM IS DEPENDENT ON THE CONFORMATION OF THE CARBOXY-TERMINAL TAIL OF THE HUMAN PROGESTERONE-RECEPTOR

E. VEGETO
G. ALLAN
W. SCHRADER
M. TSAI
D. MCDONNELL
B. OMALLEY

January 1992

The human progesterone receptor form B (hPR-B) was expressed in Saccharomyces cerevisiae together wi...

Molecular Modeling on Structure-Function Analysis of Human Progesterone Receptor Modulators

Ria PAL

June 2011

Considering the significance of progesterone receptor (PR) modulators, the present study is explored...

Structures of acetoxy progestins (pregnane steroids)

Peterson, C. Matthew

January 1998

From C. Matthew Peterson, M.D. Progestogens, Progesterone Antagonists, Progesterone, and Androgens: ...

QSAR of progestogens: Use of a priori and computed molecular descriptors and molecular graphics

Kiralj, R
Takahata, Y
Ferreira, MMC

November 2015

Quantitative Structure-Activity Relationship (QSAR) study of two sets of oral progestogens was carri...

Molecular determinants of partial agonism by progesterone receptor modulators : implications for drug design & discovery

Lusher, S.J.

January 2013

Contains fulltext : 101060.pdf (publisher's version ) (Open Access)Radboud Univers...

X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11beta-substituted steroids.

Lusher, S.J.
Raaijmakers, H.C.A.
Vu-Pham, D.
Kazemier, B.
Bosch, R.
McGuire, R.
Azevedo, R.
Hamersma, H.
Dechering, K.
Oubrie, A.
Duin, M. van
Vlieg, J. de

January 2012

Contains fulltext : 103894.pdf (publisher's version ) (Open Access)We present here...

Sci Pharm www.scipharm.at Research article Open Access Molecular Modeling on Structure-Function Analysis of Human Progesterone Receptor Modulators

Ria Pal
Md Ataul Islam
Tabassum Hossain
Achintya Saha

August 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licen...

Progesterone receptor ligand binding domain : from conformational dynamics to drug discovery

Zheng, Liangzhen

January 2019

Hormones are vital molecules for human differentiation, development, and health. Among them, the fem...

X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11beta-substituted steroids.

Lusher, S.J.
Raaijmakers, H.C.A.
Vu-Pham, D.
Kazemier, B.
Bosch, R.
McGuire, R.
Azevedo, R.
Hamersma, H.
Dechering, K.
Oubrie, A.
Duin, M. van
Vlieg, J. de

January 2012

We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed pro...

Data_Sheet_1_Ligand Binding Induces Agonistic-Like Conformational Adaptations in Helix 12 of Progesterone Receptor Ligand Binding Domain.PDF

Liangzhen Zheng (3337176)
Kelin Xia (4825065)
Yuguang Mu (29465)

May 2019

Progesterone receptor (PR) is a member of the nuclear receptor (NR) superfamily and plays a vital ro...

The progesterone receptor. Biological effects of progestins and antiprogestins

J. F. Savouret
A. Chauchereau
M. Misrahi
P. Lescop
A. Mantel
A. Bailly

January 1994

The progesterone receptor displays the typical three-domains structure of the steroid-thyroid recept...

Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton

Yuko Nishiyama (1389555)
Shuichi Mori (362273)
Makoto Makishima (294803)
Shinya Fujii (565601)
Hiroyuki Kagechika (838715)
Yuichi Hashimoto (1665289)
Minoru Ishikawa (1665292)

June 2018

The progesterone receptor (PR) plays an important role in various physiological systems, including f...

Ligand binding induces agonistic-like conformational adaptations in helix 12 of progesterone receptor ligand binding domain

Zheng, Liangzhen
Xia, Kelin
Mu, Yuguang

January 2019

Progesterone receptor (PR) is a member of the nuclear receptor (NR) superfamily and plays a vital ro...

5-benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists

Tegley, CM
Zhi, L
Marschke, KB
Gottardis, MM
Yang, QC
Jones, TK

January 1998

A novel series of nonsteroidal progestins, 5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines (2), w...

Structural aspects of agonism and antagonism in the oestrogen receptor.

Pike, AC
Brzozowski, AM
Walton, J
Hubbard, RE
Bonn, T
Gustafsson, JA
Carlquist, M

January 2000

We have determined the three-dimensional structures of both alpha- and beta-forms of the ligand-bind...

THE MECHANISM OF RU486 ANTAGONISM IS DEPENDENT ON THE CONFORMATION OF THE CARBOXY-TERMINAL TAIL OF THE HUMAN PROGESTERONE-RECEPTOR

E. VEGETO
G. ALLAN
W. SCHRADER
M. TSAI
D. MCDONNELL
B. OMALLEY

January 1992

The human progesterone receptor form B (hPR-B) was expressed in Saccharomyces cerevisiae together wi...

Molecular Modeling on Structure-Function Analysis of Human Progesterone Receptor Modulators

Ria PAL

June 2011

Considering the significance of progesterone receptor (PR) modulators, the present study is explored...

Structures of acetoxy progestins (pregnane steroids)

Peterson, C. Matthew

January 1998

From C. Matthew Peterson, M.D. Progestogens, Progesterone Antagonists, Progesterone, and Androgens: ...

QSAR of progestogens: Use of a priori and computed molecular descriptors and molecular graphics

Kiralj, R
Takahata, Y
Ferreira, MMC

November 2015

Quantitative Structure-Activity Relationship (QSAR) study of two sets of oral progestogens was carri...

Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators

Abstract

Extracted data

Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators

Abstract

Extracted data

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