Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
- Thorgeirsson, T.E.
- Gudbjartsson, D.F.
- Surakka, I.
- Vink, J.M.
- Amin, N.
- Geller, F.
- Sulem, P.
- Rafnar, T.
- Esko, T.
- Walter, S.
- Gieger, C.
- Rawal, R.
- Mangino, M.
- Prokopenko, I.
- Magi, R.
- Keskitalo, K.
- Gudjonsdottir, I.H.
- Gretarsdottir, S.
- Stefansson, H.
- Thompson, J.R.
- Aulchenko, Y.S.
- Nelis, M.
- Aben, K.K.H.
- Heijer, M. den
- Dirksen, A.
- Ashraf, H.
- Soranzo, N.
- Valdes, A.M.
- Steves, C.
- Uitterlinden, A.G.
- Hofman, A.
- Tonjes, A.
- Kovacs, P.
- Hottenga, J.J.
- Willemsen, G.
- Vogelzangs, N.
- Doring, A.
- Dahmen, N.
- Nitz, B.
- Pergadia, M.L.
- Saez, B.
- Diego, V. De
- Lezcano, V.
- Garcia-Prats, M.D.
- Ripatti, S.
- Perola, M.
- Kettunen, J.
- Hartikainen, A.L.
- Pouta, A.
- Laitinen, J.
- Isohanni, M.
- Huei-Yi, S.
- Allen, M.
- Krestyaninova, M.
- Hall, A.S.
- Jones, G.T.
- Rij, A.M. van
- Mueller, T.
- Dieplinger, B.
- Haltmayer, M.
- Jonsson, S.
- Matthiasson, S.E.
- Oskarsson, H.
- Tyrfingsson, T.
- Kiemeney, L.A.L.M.
- Mayordomo, J.I.
- Lindholt, J.S.
- Pedersen, J.H.
- Franklin, W.A.
- Wolf, H.
- Montgomery, G.W.
- Heath, A.C.
- Martin, N.G.
- Madden, P.A.F.
- Giegling, I.
- Rujescu, D.
- Jarvelin, M.R.
- Salomaa, V.
- Stumvoll, M.
- Spector, T.D.
- Wichmann, H.E.
- Metspalu, A.
- Samani, N.J.
- Penninx, B.W.J.H.
- Oostra, B.A.
- Boomsma, D.I.
- Tiemeier, H.
- Duijn, C.M. van
- Kaprio, J.
- Gulcher, J.R.
- McCarthy, M.I.
- Peltonen, L.
- Thorsteinsdottir, U.
- Stefansson, K.
DOIAbstract
Contains fulltext : 89305.pdf (publisher's version ) (Closed access)Smoking is a common risk factor for many diseases. We conducted genome-wide association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = 31,266) and smoking initiation (n = 46,481) using samples from the ENGAGE Consortium. In a second stage, we tested selected SNPs with in silico replication in the Tobacco and Genetics (TAG) and Glaxo Smith Kline (Ox-GSK) consortia cohorts (n = 45,691 smokers) and assessed some of those in a third sample of European ancestry (n = 9,040). Variants in three genomic regions associated with CPD (P < 5 x 10(-8)), including previously identified SNPs at 15q25 represented by rs1051730[A] (effect siz...
Add to ORKG