Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study.
- Oonk, M.H.
- Hemel, B.M. van
- Hollema, H.
- Hullu, J.A. de
- Ansink, A.C.
- Vergote, I.
- Verheijen, R.H.
- Maggioni, A.
- Gaarenstroom, K.N.
- Baldwin, P.J.
- Dorst, E.B. van
- Velden, J. Van der
- Hermans, R.H.
- Putten, H.W. van der
- Drouin, P.
- Runnebaum, I.B.
- Sluiter, W.J.
- Zee, A.G. van der
DOIAbstract
Contains fulltext : 89256.pdf (publisher's version ) (Closed access)BACKGROUND: Currently, all patients with vulvar cancer with a positive sentinel node undergo inguinofemoral lymphadenectomy, irrespective of the size of sentinel-node metastases. Our study aimed to assess the association between size of sentinel-node metastasis and risk of metastases in non-sentinel nodes, and risk of disease-specific survival in early stage vulvar cancer. METHODS: In the GROningen INternational Study on Sentinel nodes in Vulvar cancer (GROINSS-V), sentinel-node detection was done in patients with T1-T2 (<4 cm) squamous-cell vulvar cancer, followed by inguinofemoral lymphadenectomy if metastatic disease was identified in the sentinel node,...
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