Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.
- Nikoloski, G.
- Langemeijer, S.M.C.
- Kuiper, R.P.
- Knops, R.
- Massop, M.
- Tonnissen, E.R.
- Heijden, A. van der
- Scheele, T.N.
- Vandenberghe, P.
- Witte, T.J.M. de
- Reijden, B.A. van der
- Jansen, J.H.
Publication date
January 2010
DOI Publisher
Springer Science and Business Media LLC ISSN
1061-4036 Citation count (estimate)
480Abstract
Contains fulltext : 89188.pdf (publisher's version ) (Closed access)In myelodysplastic syndromes (MDS), deletions of chromosome 7 or 7q are common and correlate with a poor prognosis. The relevant genes on chromosome 7 are unknown. We report here that EZH2, located at 7q36.1, is frequently targeted in MDS. Analysis of EZH2 deletions, missense and frameshift mutations strongly suggests that EZH2 is a tumor suppressor. As EZH2 functions as a histone methyltransferase, abnormal histone modification may contribute to epigenetic deregulation in MDS.1 augustus 201
Add to ORKG