Add to ORKGMicroRNAs (miRNAs) form an abundant class of non‐coding RNA genes that have an important function in post‐transcriptional gene regulation and in particular modulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically located in intergenic regions in the Hox clusters of vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster duplications followed by differential gene loss
Hox genes encode a family of transcriptional regulators that operate differential developmental prog...
Hox genes encode a family of transcriptional regulators that operate differential developmental prog...
Background: MicroRNAs have been identified as crucial regulators in both animals and plants.Here we...
MicroRNAs (miRNAs) form an abundant class of non‐coding RNA genes that have an important function in...
MicroRNAs (miRNAs) form an abundant class of non-coding RNA genes that have an important function in...
Background: Introns represent a potentially rich source of existing transcription for the evolution...
The Hox genes play a key role in the determination of the anterior-posterior pattern of the metazoan...
Abstract MicroRNAs (miRs) are noncoding RNAs that regulate gene expression at the post-transcription...
Many of the known microRNAs are encoded in polycistronic transcripts. Here, we reconstruct the evolu...
This research was supported by the Hong Kong Research Grant Council GRF Grant (14103516), The Chines...
Genetic linkage may result in the expression of multiple products from a polycistronic transcript, u...
Abstract: Since the last common ancestor of Metazoa, animals have evolved complex body plans with sp...
Although numerous studies have emphasized the role of microRNAs (miRNAs) in the control of many diff...
A striking feature of microRNAs is that they are often clustered in the genomes of animals. The func...
Many microRNA (miRNA) loci exhibit compelling hairpin structures on both sense and antisense strands...
Hox genes encode a family of transcriptional regulators that operate differential developmental prog...
Hox genes encode a family of transcriptional regulators that operate differential developmental prog...
Background: MicroRNAs have been identified as crucial regulators in both animals and plants.Here we...
MicroRNAs (miRNAs) form an abundant class of non‐coding RNA genes that have an important function in...
MicroRNAs (miRNAs) form an abundant class of non-coding RNA genes that have an important function in...
Background: Introns represent a potentially rich source of existing transcription for the evolution...
The Hox genes play a key role in the determination of the anterior-posterior pattern of the metazoan...
Abstract MicroRNAs (miRs) are noncoding RNAs that regulate gene expression at the post-transcription...
Many of the known microRNAs are encoded in polycistronic transcripts. Here, we reconstruct the evolu...
This research was supported by the Hong Kong Research Grant Council GRF Grant (14103516), The Chines...
Genetic linkage may result in the expression of multiple products from a polycistronic transcript, u...
Abstract: Since the last common ancestor of Metazoa, animals have evolved complex body plans with sp...
Although numerous studies have emphasized the role of microRNAs (miRNAs) in the control of many diff...
A striking feature of microRNAs is that they are often clustered in the genomes of animals. The func...
Many microRNA (miRNA) loci exhibit compelling hairpin structures on both sense and antisense strands...
Hox genes encode a family of transcriptional regulators that operate differential developmental prog...
Hox genes encode a family of transcriptional regulators that operate differential developmental prog...
Background: MicroRNAs have been identified as crucial regulators in both animals and plants.Here we...