Item does not contain fulltextInsertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor (AR) binders and a clear insight into the structure-activity relationship of such coactivator mimics concerning helix length
Protein-protein interactions (PPIs) are attractive targets because of their therapeutic potential. ...
International audienceNatural miniproteins (e.g., animal toxins, protease inhibitors, defensins) can...
The androgen receptor (AR) is a key target for the development of drugs targeting hormone-dependent ...
Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniprotein...
A classical approach to treating prostate cancer uses antagonist ligands - so-called anti-androgens,...
The androgen receptor (AR) plays important roles in gene expression regulation, sexual phenotype mai...
The androgen receptor (AR) mediates the various actions of androgens and is responsible for the male...
The mutation-driven transformation of clinical anti-androgen drugs into agonists of the human androg...
The estrogen receptor (ER) is ligand-regulated nuclear hormone receptor and an important therapeutic...
This work focuses on designing specific miniprotein interactions using computational models and then...
In this study, molecular simulations have been combined with site-directed mutagenesis experiments t...
Ligands for the androgen receptor (AR), androgens and antiandrogens alike, have therapeutic value in...
When a small molecule binds to the androgen receptor (AR), a conformational change can occur which i...
<p>When a small molecule binds to the androgen receptor (AR), a conformational change can occur whic...
We describe the design, using shape comparison and fast docking computer algorithms, and rapid paral...
Protein-protein interactions (PPIs) are attractive targets because of their therapeutic potential. ...
International audienceNatural miniproteins (e.g., animal toxins, protease inhibitors, defensins) can...
The androgen receptor (AR) is a key target for the development of drugs targeting hormone-dependent ...
Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniprotein...
A classical approach to treating prostate cancer uses antagonist ligands - so-called anti-androgens,...
The androgen receptor (AR) plays important roles in gene expression regulation, sexual phenotype mai...
The androgen receptor (AR) mediates the various actions of androgens and is responsible for the male...
The mutation-driven transformation of clinical anti-androgen drugs into agonists of the human androg...
The estrogen receptor (ER) is ligand-regulated nuclear hormone receptor and an important therapeutic...
This work focuses on designing specific miniprotein interactions using computational models and then...
In this study, molecular simulations have been combined with site-directed mutagenesis experiments t...
Ligands for the androgen receptor (AR), androgens and antiandrogens alike, have therapeutic value in...
When a small molecule binds to the androgen receptor (AR), a conformational change can occur which i...
<p>When a small molecule binds to the androgen receptor (AR), a conformational change can occur whic...
We describe the design, using shape comparison and fast docking computer algorithms, and rapid paral...
Protein-protein interactions (PPIs) are attractive targets because of their therapeutic potential. ...
International audienceNatural miniproteins (e.g., animal toxins, protease inhibitors, defensins) can...
The androgen receptor (AR) is a key target for the development of drugs targeting hormone-dependent ...
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