Occurrence of postmenopausal-like acidic follicle-stimulating hormone (FSH) isoforms precedes the rise of FSH before menopause.
- Thomas, C.M.G.
- Span, P.N.
- Smeenk, J.M.J.
- Hanssen, R.G.
- Braat, D.D.M.
- Sweep, C.G.J.
DOIAbstract
Contains fulltext : 81450.pdf (publisher's version ) (Closed access)OBJECTIVE: To assess the glycoform distribution patterns of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) during the menstrual cycle at different ages and FSH levels, after menopause, and with premature ovarian failure (POF). DESIGN: Controlled clinical study. SETTING: Healthy volunteers in an academic research environment. PATIENT(S): Women aged 20 to 25 years with normal early follicular (EF) serum FSH (<10 IU/L), women aged 40 to 45 years with normal or increased EF serum FSH, postmenopausal women, and women with POF. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): FSH and LH glycoform distributions as assessed by chromatofocusing. RES...
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