Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.
- Wu, X.
- Ye, Y.
- Kiemeney, L.A.L.M.
- Sulem, P.
- Rafnar, T.
- Matullo, G.
- Seminara, D.
- Yoshida, T.
- Saeki, N.
- Andrew, A.S.
- Dinney, C.P.
- Czerniak, B.
- Zhang, Z.F.
- Kiltie, A.E.
- Bishop, D.T.
- Vineis, P.
- Porru, S.
- Buntinx, F.
- Kellen, E.
- Zeegers, M.P.
- Kumar, R.
- Rudnai, P.
- Gurzau, E
- Koppova, K.
- Mayordomo, J.I.
- Sanchez, M.
- Saez, B.
- Lindblom, A.
- Verdier, P. de
- Steineck, G.
- Mills, G.B.
- Schned, A.
- Guarrera, S.
- Polidoro, S.
- Chang, S.C.
- Lin, J.
- Chang, D.W.
- Hale, K.S.
- Majewski, T.
- Grossman, H.B.
- Thorlacius, S.
- Thorsteinsdottir, U.
- Aben, K.K.H.
- Witjes, J.A.
- Stefansson, K.
- Amos, C.I.
- Karagas, M.R.
- Gu, J.
DOIAbstract
Contains fulltext : 80627.pdf (publisher's version ) (Closed access)We conducted a genome-wide association study on 969 bladder cancer cases and 957 controls from Texas. For fast-track validation, we evaluated 60 SNPs in three additional US populations and validated the top SNP in nine European populations. A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations. Combining all subjects (6,667 cases, 39,590 controls), the overall P-value was 2.14 x 10(-10) and the allelic odds ratio was 1.15 (95% confidence interval 1.10-1.20). rs2294008 alters the start codon and is predicted to cause truncation of nine amino acids from the N-terminal signal sequence ...
Add to ORKG