Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.
- Kiemeney, L.A.L.M.
- Thorlacius, S.
- Sulem, P.
- Geller, F.
- Aben, K.K.H.
- Stacey, S.N.
- Gudmundsson, J.
- Jakobsdottir, M.
- Bergthorsson, J.T.
- Sigurdsson, A.
- Blondal, T.
- Witjes, J.A.
- Vermeulen, H.H.M.
- Hulsbergen-van de Kaa, C.A.
- Swinkels, D.W.
- Ploeg, M.
- Cornel, E.B.
- Vergunst, H.
- Thorgeirsson, T.E.
- Gudbjartsson, D.F.
- Gudjonsson, S.A.
- Thorleifsson, G.
- Kristinsson, K.T.
- Mouy, M.
- Snorradottir, S.
- Placidi, D.
- Campagna, M.
- Arici, C.
- Koppova, K.
- Gurzau, E
- Rudnai, P.
- Kellen, E.
- Polidoro, S.
- Guarrera, S.
- Sacerdote, C.
- Sanchez, M.
- Saez, B.
- Valdivia, G.
- Ryk, C.
- Verdier, P. de
- Lindblom, A.
- Golka, K.
- Bishop, D.T.
- Knowles, M.A.
- Nikulasson, S.
- Petursdottir, V.
- Jonsson, E.
- Geirsson, G.
- Kristjansson, B.
- Mayordomo, J.I.
- Steineck, G.
- Porru, S.
- Buntinx, F.
- Zeegers, M.
- Fletcher, T.
- Kumar, R.
- Matullo, G.
- Vineis, P.
- Kiltie, A.E.
- Gulcher, J.R.
- Thorsteinsdottir, U.
- Kong, A.
- Rafnar, T.
- Stefansson, K.
DOIAbstract
Contains fulltext : 71044.pdf (publisher's version ) (Closed access)We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associate...
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