Evaluation of the biocompatibility of calcium phosphate cement/PLGA microparticle composites.
- Link, D.P.
- Dolder, J. van den
- Beucken, J.J.J.P van den
- Cuijpers, V.M.J.I.
- Wolke, J.G.C.
- Mikos, A.G.
- Jansen, J.A.
DOIAbstract
Contains fulltext : 70339.pdf (publisher's version ) (Open Access)In this study, the biocompatibility of a calcium phosphate (CaP) cement incorporating poly (D,L-lactic-co-glycolic acid) (PLGA) microparticles was evaluated in a subcutaneous implantation model in rats. Short-term biocompatibility was assessed using pure CaP discs and CaP discs incorporating PLGA microparticles (20% w/w) with and without preincubation in water. Long-term biocompatibility was assessed using CaP discs incorporating varying amounts (5, 10, or 20% w/w) and diameter sizes (small, 0-50 mum; medium, 51-100 mum, or large, 101-200 mum) of PLGA microparticles. The short-term biocompatibility results showed a mild tissue response for all implant formul...
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