Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins
- Wang, Yunzhang
- Karlsson, Robert
- Lampa, Erik
- Zhang, Qian
- Hedman, Åsa K.
- Almgren, Malin
- Almqvist, Catarina
- McRae, Allan F.
- Marioni, Riccardo E.
- Ingelsson, Erik
- Visscher, Peter M.
- Deary, Ian J.
- Lind, Lars
- Morris, Tiffany
- Beck, Stephan
- Pedersen, Nancy L.
- Hägg, Sara
Publication date
January 2018
DOI Publisher
Informa UK Limited ISSN
1559-2294 Citation count (estimate)
5Abstract
Age-related changes in DNA methylation were observed in cross-sectional studies, but longitudinal evidence is still limited. Here, we aimed to characterize longitudinal age-related methylation patterns using 1011 blood samples collected from 385 Swedish twins (age at entry: mean 69 and standard deviation 9.7, 73 monozygotic and 96 dizygotic pairs) up to five times (mean 2.6) over 20 years (mean 8.7). We identified 1316 age-associated methylation sites (
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