Orthopedic implant infections are a significant clinical problem, with current therapies limited to surgical debridement and systemic antibiotic regimens. Lysostaphin is a bacteriolytic enzyme with high antistaphylococcal activity. We engineered a lysostaphin-delivering injectable PEG hydrogel to treat Staphylococcus aureus infections in bone fractures. The injectable hydrogel formulation adheres to exposed tissue and fracture surfaces, ensuring efficient, local delivery of lysostaphin. Lysostaphin encapsulation within this synthetic hydrogel maintained enzyme stability and activity. Lysostaphin-delivering hydrogels exhibited enhanced antibiofilm activity compared with soluble lysostaphin. Lysostaphin-delivering hydrogels eradicated S. aure...
Infectious complications occur in a minor but significant portion of the patients undergoing joint r...
Local prophylaxis with antibiotic-loaded bone cement is a successful method to prevent post-operativ...
<div><p><i>Staphylococcus</i> comprises up to two-thirds of all pathogens in orthopaedic implant inf...
Orthopedic implant infections are a significant clinical problem, with current therapies limited to ...
Orthopaedic hardware infections are a significant clinical problem with current therapies limited to...
The increasing incidence of implant-associated infections induced by Staphylococcus aureus (SA) in c...
Antibiotic-loaded biomaterials (ALBs) have emerged as a potentially useful adjunctive antimicrobial ...
Local antibiotic therapy is increasingly being recognised for its role in preventing and treating or...
The increasing incidence of implant-associated infections induced by Staphylococcus aureus (SA) in c...
Despite the use of systemic antibiotic prophylaxis, the surgical fixation of open fractures with ost...
Bone infection is a dreaded complication in orthopedic trauma surgery which can severely delay or pr...
An innovative delivery system based on bacteriophages-loaded alginate-nanohydroxyapatite hydrogel wa...
IntroductionTreatment of open fractures routinely involves multiple surgeries and delayed definitive...
Open fractures are at risk of serious infection and, if infected, require several surgical intervent...
Wound infections are prone to attacks from infectious pathogens, including multidrug resistant bacte...
Infectious complications occur in a minor but significant portion of the patients undergoing joint r...
Local prophylaxis with antibiotic-loaded bone cement is a successful method to prevent post-operativ...
<div><p><i>Staphylococcus</i> comprises up to two-thirds of all pathogens in orthopaedic implant inf...
Orthopedic implant infections are a significant clinical problem, with current therapies limited to ...
Orthopaedic hardware infections are a significant clinical problem with current therapies limited to...
The increasing incidence of implant-associated infections induced by Staphylococcus aureus (SA) in c...
Antibiotic-loaded biomaterials (ALBs) have emerged as a potentially useful adjunctive antimicrobial ...
Local antibiotic therapy is increasingly being recognised for its role in preventing and treating or...
The increasing incidence of implant-associated infections induced by Staphylococcus aureus (SA) in c...
Despite the use of systemic antibiotic prophylaxis, the surgical fixation of open fractures with ost...
Bone infection is a dreaded complication in orthopedic trauma surgery which can severely delay or pr...
An innovative delivery system based on bacteriophages-loaded alginate-nanohydroxyapatite hydrogel wa...
IntroductionTreatment of open fractures routinely involves multiple surgeries and delayed definitive...
Open fractures are at risk of serious infection and, if infected, require several surgical intervent...
Wound infections are prone to attacks from infectious pathogens, including multidrug resistant bacte...
Infectious complications occur in a minor but significant portion of the patients undergoing joint r...
Local prophylaxis with antibiotic-loaded bone cement is a successful method to prevent post-operativ...
<div><p><i>Staphylococcus</i> comprises up to two-thirds of all pathogens in orthopaedic implant inf...