Add to ORKGGlioblastoma is the most common and malignant form of primary astrocytoma. Upon investigation of the insulin-like growth factor (IGF) pathway, we found the IGF2BP3/IMP3 transcript and protein to be up-regulated in GBMs but not in lower grade astrocytomas (p<0.0001). IMP3 is an RNA binding protein known to bind to the 5'-untranslated region of IGF-2 mRNA, thereby activating its translation. Overexpression-and knockdown-based studies establish a role for IMP3 in promoting proliferation, anchorage-independent growth, invasion, and chemoresistance. IMP3 overexpressing B16F10 cells also showed increased tumor growth, angiogenesis, and metastasis, resulting in poor survival in a mouse model. Additionally, the infiltrating front, perivascular, and...
BackgroundThe human insulin-like growth factor 2 mRNA binding proteins 1–3 (IGF2BP1–3, also called I...
The gene encoding the Insulin-like Growth Factor 2 mRNA binding protein 2/IMP2 is amplified and over...
Insulin-like growth factor binding proteins (IGFBP) are known to modulate the actions of insulin-lik...
Glioblastoma is the most common and malignant form of primary astrocytoma. Upon investigation of the...
Glioblastoma is the most common and malignant form of primary astrocytoma with a short median surviv...
Chao Wu, Hongxin Ma, Guijun Qi, Fanyu Chen, Jiancheng ChuDepartment of Neurosurgery, Tengzhou Centra...
The diffusely infiltrative nature of glioblastoma (GBM) makes them highly recurrent. IGF2 mRNA-bindi...
The diffusely infiltrative nature of glioblastoma (GBM) makes them highly recurrent. IGF2 mRNA-bindi...
Comparison of gene expressing profiles between gliomas with different grades revealed frequent overe...
Abstract Background The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3...
Gliomas are clinically challenging brain tumors with dismal survival rates due to its infiltrative n...
BackgroundThe human insulin-like growth factor 2 mRNA binding proteins 1–3 (IGF2BP1–3, also called I...
BackgroundThe human insulin-like growth factor 2 mRNA binding proteins 1–3 (IGF2BP1–3, also called I...
RNA binding proteins mediate global regulation at the level of transcriptome and translatome of a ce...
Diffuse gliomas are highly lethal central nervous system malignancies which, unfortunately, are the ...
BackgroundThe human insulin-like growth factor 2 mRNA binding proteins 1–3 (IGF2BP1–3, also called I...
The gene encoding the Insulin-like Growth Factor 2 mRNA binding protein 2/IMP2 is amplified and over...
Insulin-like growth factor binding proteins (IGFBP) are known to modulate the actions of insulin-lik...
Glioblastoma is the most common and malignant form of primary astrocytoma. Upon investigation of the...
Glioblastoma is the most common and malignant form of primary astrocytoma with a short median surviv...
Chao Wu, Hongxin Ma, Guijun Qi, Fanyu Chen, Jiancheng ChuDepartment of Neurosurgery, Tengzhou Centra...
The diffusely infiltrative nature of glioblastoma (GBM) makes them highly recurrent. IGF2 mRNA-bindi...
The diffusely infiltrative nature of glioblastoma (GBM) makes them highly recurrent. IGF2 mRNA-bindi...
Comparison of gene expressing profiles between gliomas with different grades revealed frequent overe...
Abstract Background The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3...
Gliomas are clinically challenging brain tumors with dismal survival rates due to its infiltrative n...
BackgroundThe human insulin-like growth factor 2 mRNA binding proteins 1–3 (IGF2BP1–3, also called I...
BackgroundThe human insulin-like growth factor 2 mRNA binding proteins 1–3 (IGF2BP1–3, also called I...
RNA binding proteins mediate global regulation at the level of transcriptome and translatome of a ce...
Diffuse gliomas are highly lethal central nervous system malignancies which, unfortunately, are the ...
BackgroundThe human insulin-like growth factor 2 mRNA binding proteins 1–3 (IGF2BP1–3, also called I...
The gene encoding the Insulin-like Growth Factor 2 mRNA binding protein 2/IMP2 is amplified and over...
Insulin-like growth factor binding proteins (IGFBP) are known to modulate the actions of insulin-lik...