Add to ORKGOwing to high evolutionary divergence, it is not always possible to identify distantly related protein domains by sequence search techniques. Intermediate sequences possess sequence features of more than one protein and facilitate detection of remotely related proteins. We have demonstrated recently the employment of Cascade PSI-BLAST where we perform PSI-BLAST for many 'generations', initiating searches from new homologues as well. Such a rigorous propagation through generations of PSI-BLAST employs effectively the role of intermediates in detecting distant similarities between proteins. This approach has been tested on a large number of folds and its performance in detecting superfamily level relationships is similar to 35% better than si...
Abstract RESULTS: A WWW server for protein domain homology prediction, based on BLAST...
Using a number of diverse protein families as test cases, we investigate the ability of the recently...
Proteins evolve by mutations and natural selec-tion. The network of sequence similarities is a rich ...
Owing to high evolutionary divergence, it is not always possible to identify distantly related prote...
Owing to high evolutionary divergence, it is not always possible to identify distantly related prote...
Profile-based sequence search procedures are commonly employed to detect remote relationships betwee...
and 13 other families of unrelated folds to identify the distant homologues which could not be obta...
Over the past two decades, many ingenious efforts have been made in protein remote homology detectio...
One of the fundamental challenges in computational biology is the identification of evolutionarily r...
AbstractProfile matching methods are commonly used in searches in protein sequence databases to dete...
Profile matching methods are commonly used in searches in protein sequence databases to detect evolu...
Alam I. Integrative approaches to protein homology search. Bielefeld (Germany): Bielefeld University...
Virtually every molecular biologist has searched a protein or DNA sequence database to find sequence...
Protein families often are characterized by conserved sequence patterns or motifs. A researcher freq...
Background: Development of sensitive sequence search procedures for the detection of distant relatio...
Abstract RESULTS: A WWW server for protein domain homology prediction, based on BLAST...
Using a number of diverse protein families as test cases, we investigate the ability of the recently...
Proteins evolve by mutations and natural selec-tion. The network of sequence similarities is a rich ...
Owing to high evolutionary divergence, it is not always possible to identify distantly related prote...
Owing to high evolutionary divergence, it is not always possible to identify distantly related prote...
Profile-based sequence search procedures are commonly employed to detect remote relationships betwee...
and 13 other families of unrelated folds to identify the distant homologues which could not be obta...
Over the past two decades, many ingenious efforts have been made in protein remote homology detectio...
One of the fundamental challenges in computational biology is the identification of evolutionarily r...
AbstractProfile matching methods are commonly used in searches in protein sequence databases to dete...
Profile matching methods are commonly used in searches in protein sequence databases to detect evolu...
Alam I. Integrative approaches to protein homology search. Bielefeld (Germany): Bielefeld University...
Virtually every molecular biologist has searched a protein or DNA sequence database to find sequence...
Protein families often are characterized by conserved sequence patterns or motifs. A researcher freq...
Background: Development of sensitive sequence search procedures for the detection of distant relatio...
Abstract RESULTS: A WWW server for protein domain homology prediction, based on BLAST...
Using a number of diverse protein families as test cases, we investigate the ability of the recently...
Proteins evolve by mutations and natural selec-tion. The network of sequence similarities is a rich ...