A new class of 1,3,4-oxadiazoles were prepared from acid hydrazides on treatment with different carboxylic acids in the presence of phosphorus oxychloride. Interconversion of oxadiazoles to thiadiazoles and triazoles was carried out with appropriate reagents. The antimicrobial and cytotoxic activities of compounds 7a-d to 12a-d were tested. Compounds 10d and 12d showed pronounced antimicrobial activity. Further, compound 10d exhibited maximum cytotoxicity. (C) 2008 Elsevier Masson SAS. All rights reserved
New series of 1,3,4-thiadiazoles have been prepared via reaction of 1,3,4-thiadiazolenaminones 1 wit...
208-211Methyl acrylate on treatment with aryl thiols gives methyl 3-(arylthio) propanoates. The lat...
Reaction of 1-adamantanecarbonyl chloride with certain carboxylic acid hydrazides in pyridine yielde...
Oxadiazole is amongst the important classes of heterocyclic compounds that is the subject of intensi...
Novel derivatives of 1,2,4,-triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole were synthesized from c...
2189-2194The synthesis and biological activities (anti-inflammatory and antibacterial) of a number ...
In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1...
In attempt to find new pharmacologically active molecules, we report here the synthesis and in vi...
A new class of sulfonamidomethane pyrrolyl-oxadiazoles/thiadiazoles and pyrazolyl-oxadiazoles/thiadi...
Twelve novel triazolothiadiazole derivatives were synthesized from 4-amino-5-substituted-4H-1,2,4-tr...
We have reported some novel 1,3,4-oxadiazole synthesized by conventional method .The reaction of 5-b...
A series of semicarbazones, thiosemicarbazones, 1,3,4-oxadiazoles/thiadiazoles bearing pyrazole scaf...
1,3,4-oxadiazoles are interesting compounds because of their valuable biological effects such as cyt...
A new class of heterocycles pyrrolyl thiadiazoles, pyrrolyl oxadiazoles and pyrrolyl triazoles were ...
A series of 1,3-oxazole, 1,3-thiazole, isomeric 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,3,4-tetr...
New series of 1,3,4-thiadiazoles have been prepared via reaction of 1,3,4-thiadiazolenaminones 1 wit...
208-211Methyl acrylate on treatment with aryl thiols gives methyl 3-(arylthio) propanoates. The lat...
Reaction of 1-adamantanecarbonyl chloride with certain carboxylic acid hydrazides in pyridine yielde...
Oxadiazole is amongst the important classes of heterocyclic compounds that is the subject of intensi...
Novel derivatives of 1,2,4,-triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole were synthesized from c...
2189-2194The synthesis and biological activities (anti-inflammatory and antibacterial) of a number ...
In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1...
In attempt to find new pharmacologically active molecules, we report here the synthesis and in vi...
A new class of sulfonamidomethane pyrrolyl-oxadiazoles/thiadiazoles and pyrazolyl-oxadiazoles/thiadi...
Twelve novel triazolothiadiazole derivatives were synthesized from 4-amino-5-substituted-4H-1,2,4-tr...
We have reported some novel 1,3,4-oxadiazole synthesized by conventional method .The reaction of 5-b...
A series of semicarbazones, thiosemicarbazones, 1,3,4-oxadiazoles/thiadiazoles bearing pyrazole scaf...
1,3,4-oxadiazoles are interesting compounds because of their valuable biological effects such as cyt...
A new class of heterocycles pyrrolyl thiadiazoles, pyrrolyl oxadiazoles and pyrrolyl triazoles were ...
A series of 1,3-oxazole, 1,3-thiazole, isomeric 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,3,4-tetr...
New series of 1,3,4-thiadiazoles have been prepared via reaction of 1,3,4-thiadiazolenaminones 1 wit...
208-211Methyl acrylate on treatment with aryl thiols gives methyl 3-(arylthio) propanoates. The lat...
Reaction of 1-adamantanecarbonyl chloride with certain carboxylic acid hydrazides in pyridine yielde...