In vitro models of the neuromuscular junction (NMJ) are emerging as a valuable tool to study synaptogenesis, synaptic maintenance, and pathogenesis of neurodegenerative diseases. Many models have previously been developed using a variety of cell sources for muscle and motoneurons, but the models can be further improved by integrating beneficial features to better mimic the native milieu of NMJ development. We created a functional in vitro model of NMJ by bioreactor cultivation of C2C12 myoblasts, transdifferentiated myocytes and stem cell-derived motoneurons with electrical stimulation. Proper coculture medium and electrical stimulation led to improved functional coupling between the emerging motoneurons and myocytes, as evidenced by mature...
Modern neuroscience relies heavily on sophisticated tools that allow us to visualize and manipulate ...
The Taxus cell cultures primarily used in the Roberts laboratory are twenty-five years old and have ...
Adult neurogenesis has been the focus of over 1500 articles in the past 10 years. Evidence for the c...
The peripheral nervous system (PNS) is composed of a diverse array of neurons that mediate sensation...
Coordinated motor function is achieved by proper communication between motor neurons and muscle fibe...
The effectiveness of synaptic transmission at most mammalian synapses depends largely on the mainten...
Skeletal muscle is highly responsive to changes in mechanical load or activity and can adjust its mo...
Stem cells are defined by their capacity to differentiate into different phenotypes while maintainin...
Amyotrophic Lateral Sclerosis (ALS) is a fatal adult-onset paralytic disorder for which there is cur...
Abstract Modulating molecular chaperones is emerging as an attractive approach to treat neurodegener...
During neurogenic muscle atrophy, the interruption of transmission of neurogenic signals to the musc...
Nature inspires us to address the most contemporary scientific challenges. Advances in t...
The thesis presented has four goals: to perform a comprehensive literature review on current neurost...
Neural Stem Cells (NSC) perform a very important role during brain development as they are involved ...
Candida albicans is one of the most common fungal pathogens associated with opportunistic and nosoco...
Modern neuroscience relies heavily on sophisticated tools that allow us to visualize and manipulate ...
The Taxus cell cultures primarily used in the Roberts laboratory are twenty-five years old and have ...
Adult neurogenesis has been the focus of over 1500 articles in the past 10 years. Evidence for the c...
The peripheral nervous system (PNS) is composed of a diverse array of neurons that mediate sensation...
Coordinated motor function is achieved by proper communication between motor neurons and muscle fibe...
The effectiveness of synaptic transmission at most mammalian synapses depends largely on the mainten...
Skeletal muscle is highly responsive to changes in mechanical load or activity and can adjust its mo...
Stem cells are defined by their capacity to differentiate into different phenotypes while maintainin...
Amyotrophic Lateral Sclerosis (ALS) is a fatal adult-onset paralytic disorder for which there is cur...
Abstract Modulating molecular chaperones is emerging as an attractive approach to treat neurodegener...
During neurogenic muscle atrophy, the interruption of transmission of neurogenic signals to the musc...
Nature inspires us to address the most contemporary scientific challenges. Advances in t...
The thesis presented has four goals: to perform a comprehensive literature review on current neurost...
Neural Stem Cells (NSC) perform a very important role during brain development as they are involved ...
Candida albicans is one of the most common fungal pathogens associated with opportunistic and nosoco...
Modern neuroscience relies heavily on sophisticated tools that allow us to visualize and manipulate ...
The Taxus cell cultures primarily used in the Roberts laboratory are twenty-five years old and have ...
Adult neurogenesis has been the focus of over 1500 articles in the past 10 years. Evidence for the c...